Evidence map›Paper›PMID 40775285›Full record

ArticleRenal failure2025

Contrast-enhanced ultrasound and elastography predict histopathology and recovery in acute kidney injury.

Xiangyu Wang, Jiajia Liu, Luzeng Chen, Tao Su

Abstract read
In one paragraph

Article in Renal failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Xiangyu WangDepartment of Ultrasound Medicine, Peking University First Hospital, Beijing, China.
Jiajia LiuDepartment of Medicine, Renal Division, Peking University First Hospital, Beijing, China.
Luzeng ChenDepartment of Ultrasound Medicine, Peking University First Hospital, Beijing, China.
Tao SuDepartment of Medicine, Renal Division, Peking University First Hospital, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAcute kidney injury (AKI) progression involves complex microcirculatory and structural changes poorly captured by conventional metrics. This study investigates contrast-enhanced ultrasound (CEUS) and shear wave elastography (SWE) to evaluate hemodynamic redistribution and fibrosis in AKI patients.

methodsProspective cohort study of 16 biopsy-confirmed tubulointerstitial (TI) nephritis patients and matched controls. We aim to explore the potential correlation of CEUS-SWE derived parameters (peak intensity (PI), rise time (RT), time to peak (TTP), and shear wave velocity (SWV)) with renal histopathology and 3-month outcomes (renal recovery: estimated glomerular filtration rate (eGFR) ≥45 mL/min/1.73 m

resultsCEUS revealed stage-specific perfusion patterns: milder AKI (eGFR >25 mL/min/1.73 m

conclusionsCEUS-derived PI ratios quantify microcirculatory dysfunction in AKI, correlating with chronic TI injury and predicting recovery.

Indexed as

Acute Kidney InjuryElasticity Imaging TechniquesKidneyAdultAgedBiopsyCase-Control StudiesContrast MediaFemaleFibrosisGlomerular Filtration RateHumansMaleMicrocirculationMiddle AgedProspective StudiesContrast MediaAcute kidney injurychroniccontrast-enhanced ultrasonographyelastography ultrasonographytubulointerstitial injury

Identifiers

PMID40775285
PMCPMC12332991

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.