Evidence map›Paper›PMID 40775443›Full record

ArticleScientific reports2025

Screening and identification of muscle pericyte selective markers.

Jingsong Ruan, Minkyung Kang, Rong Wang, Wanling Xuan, Feng Cheng, Yao Yao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. A who's who of cell types in skeletal muscle.Communications biology · 2026
    Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jingsong RuanDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, 12901 Bruce B. Downs Blvd., MDC 8, Tampa, FL, 33612, USA.
Minkyung KangDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, 12901 Bruce B. Downs Blvd., MDC 8, Tampa, FL, 33612, USA.
Rong WangDepartment of Pharmaceutical Sciences, Taneja College of Pharmacy, University of South Florida, Tampa, FL, USA.
Wanling XuanDepartment of Pharmaceutical Sciences, Taneja College of Pharmacy, University of South Florida, Tampa, FL, USA.
Feng ChengDepartment of Pharmaceutical Sciences, Taneja College of Pharmacy, University of South Florida, Tampa, FL, USA.
Yao YaoDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, 12901 Bruce B. Downs Blvd., MDC 8, Tampa, FL, 33612, USA. yao7@usf.edu.ORCID http://orcid.org/0000-0001-8020-9696

Funding

Fibroblast-derived laminin regulates blood-brain barrier integrity and fibroblast biology in hemorrhagic brainR01NS134134 · NINDS · UNIVERSITY OF SOUTH FLORIDA · PI Yao Yao · 2023 to 2026
$2.0M
Endothelial laminin in blood brain barrier regulationR01HL146574 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI YAO, YAO · 2019 to 2023
$1.9M
The roles of pericyte-derived laminin in neurovascular function and neurodegenerationR01AG065345 · NIA · UNIVERSITY OF SOUTH FLORIDA · PI YAO, YAO · 2024 to 2025
$1.2M
Screening and identification of pericyte-specific and subpopulation-specific markersR21AG064422 · NIA · UNIVERSITY OF SOUTH FLORIDA · PI YAO, YAO · 2020 to 2021
$415k
Brain extracellular matrix changes during normal aging and in Alzheimer diseaseR21AG091884 · NIA · UNIVERSITY OF SOUTH FLORIDA · PI YAO, YAO · 2025 to 2025
$413k
Cell-specific changes of laminin expression in the CNS in Alzheimer’s diseaseR21AG073862 · NIA · UNIVERSITY OF SOUTH FLORIDA · PI YAO, YAO · 2021 to 2021
$411k
NHLBI NIH HHS R01 HL146574NHLBI NIH HHS R01HL146574NIA NIH HHS R01 AG065345NIA NIH HHS R01AG065345NIA NIH HHS R21 AG064422NIA NIH HHS R21 AG073862NIA NIH HHS R21 AG091884NINDS NIH HHS R01 NS134134NINDS NIH HHS R01NS134134
6 · The paper itself

Abstract

Pericytes, which share markers with smooth muscle cells (SMCs), are heterogenous cells. Pericytes in the brain and skeletal muscle have different embryonic origins, representing distinct subpopulations. One challenge in the field is that there are no subpopulation-specific pericyte markers. Here, we compared the transcriptomes of muscle pericytes and SMCs, and identified 741 muscle pericyte-enriched genes and 564 muscle SMC-enriched genes. Gene ontology analysis uncovered distinct biological processes and molecular functions in muscle pericytes and SMCs. Interestingly, the Venn diagram revealed only one gene shared by brain and muscle pericytes, suggesting that they are indeed distinct subpopulations with different transcriptional profiles. We further validated that GSN co-localized with PDGFRβ

Indexed as

Muscle, SkeletalMyocytes, Smooth MusclePericytesAnimalsBiomarkersBrainGene Expression ProfilingMiceReceptor, Platelet-Derived Growth Factor betaTranscriptomeBiomarkersReceptor, Platelet-Derived Growth Factor betaGenetic toolPDGFRβPericytesSM22αSmooth muscle cells

Identifiers

PMID40775443
PMCPMC12332025

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.