Evidence map›Paper›PMID 40775473›Full record

ArticlePediatric cardiology2026

Single Nucleotide Polymorphisms and Their Association with Coronary Artery Aneurysms and IVIG Resistance in Kawasaki Disease in Ireland.

S M Duignan, K Brennan, E Connolly, A Watson, D Noone, E Dunne, P Gavin, A Flinn, C Ó Maoldomhnaigh, S L Doyle and 1 more

Abstract read
In one paragraph

Article in Pediatric cardiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

S M Duignan *Department of Paediatric Cardiology, Children's Health Ireland at Crumlin, Dublin, Dublin 12, Ireland.
K Brennan *Department of Clinical Medicine, School of Medicine, Trinity College Dublin, Dublin, Ireland.
E ConnollyDepartment of Clinical Medicine, School of Medicine, Trinity College Dublin, Dublin, Ireland.
A WatsonDepartment of Clinical Medicine, School of Medicine, Trinity College Dublin, Dublin, Ireland.
D NooneDepartment of Clinical Medicine, School of Medicine, Trinity College Dublin, Dublin, Ireland.
E DunneDepartment of Paediatric Cardiology, Children's Health Ireland at Crumlin, Dublin, Dublin 12, Ireland.
P GavinDepartment of Paediatric Infectious Diseases, Children's Health Ireland at Crumlin, Dublin, Ireland.
A FlinnDepartment of Paediatric Infectious Diseases, Children's Health Ireland at Crumlin, Dublin, Ireland.
C Ó MaoldomhnaighDepartment of Clinical Medicine, School of Medicine, Trinity College Dublin, Dublin, Ireland.
S L Doyle *Department of Clinical Medicine, School of Medicine, Trinity College Dublin, Dublin, Ireland.
C J McMahon *Department of Paediatric Cardiology, Children's Health Ireland at Crumlin, Dublin, Dublin 12, Ireland. cmcmahon992004@yahoo.com.ORCID http://orcid.org/0000-0003-0337-9338

Funding

National Children's Research Centre G/19/1
6 · The paper itself

Abstract

Kawasaki disease (KD) is the leading cause of acquired heart disease in children in developed countries. The exact aetiology remains a mystery but genetics play an important role. Treatment with intravenous immunoglobulin (IVIG) successfully reduces the prevalence of coronary artery aneurysm (CAA) formation, however, IVIG resistance affects 10-20% of patients. We aimed to assess whether single nucleotide polymorphisms (SNPs) which have been associated with KD in other populations are also relevant in our national cohort. Samples were collected via buccal swabs and genotyping was performed using KASP Genotyping Assay at LGC Genomics. Chi-square (χ

Indexed as

Coronary AneurysmDrug ResistanceImmunoglobulins, IntravenousMucocutaneous Lymph Node SyndromePolymorphism, Single NucleotideVascular Endothelial Growth Factor AChildChild, PreschoolFemaleGene FrequencyGenetic Predisposition to DiseaseGenotypeHumansInfantIrelandMaleImmunoglobulins, IntravenousVascular Endothelial Growth Factor ACoronary artery aneurysmGeneticsIVIG resistanceKawasaki diseaseSNP

Identifiers

PMID40775473
PMCPMC13144236

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.