ReviewApoptosis : an international journal on programmed cell death2025
Targeting cuproptosis in liver cancer: Molecular mechanisms and therapeutic implications.
Review in Apoptosis : an international journal on programmed cell death, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Metal ion-amplified phototherapy for tumors: Mechanisms, nanomaterial design, and synergistic strategies.Materials today. Bio · 2026Review
- Development and validation of a cuproptosis-related gene signature for predicting prognosis and drug sensitivity in gastric cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Article
- Targeting copper death-related long non-coding RNAs: a novel strategy to overcome immunotherapy resistance in liver cancer.Frontiers in immunology · 2026Review
- TRIM47-facilitated PLK1 stabilization promotes the proliferation of liver cancer cells.Cellular oncology (Dordrecht, Netherlands) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Liver cancer (LC) stands as one of the most prevalent and highly malignant tumors globally, with persistently elevated mortality rates. For advanced-stage LC, identifying efficacious treatment modalities remains a critical imperative. Cuproptosis, a newly identified form of regulated cell death, exhibits therapeutic potential for impeding LC progression. However, the current clinical evidence remains limited, meriting further in-depth investigation by researchers. Existing literature has summarized copper homeostasis, the molecular mechanisms of cuproptosis, and its roles in certain cancers. However, key challenges in clinical translation haven't been included in the research scope, such as the mechanistic complexity, poor targeting specificity, lack of mature biomarkers, and risk of therapeutic resistance. Notably, the lessons from failed clinical trials have not been fully integrated into ongoing investigations. This review systematically delineates cuproptosis-associated biomarkers in LC, critically analyzes the challenges of targeting cuproptosis for LC therapy and discusses potential solutions. By highlighting current research gaps, we aim to provide actionable research directions for future investigations.
Indexed as
Identifiers
40775595What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.