ArticleRenal failure2025
Curcumin/piperine modulates the butyrate levels and alleviates diabetic kidney disease via Nrf2/HO-1 signaling pathway.
Article in Renal failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
7 citing papers in PubMed.
- Curcumin Attenuates Decidual Stromal Cell Ferroptosis and Restores Impaired Decidualization in Recurrent Spontaneous Abortion by Targeting BRD4.Food science & nutrition · 2026Article
- The alkaloid-rich extract of Piper sintenense Hatusima alleviates gouty inflammatory response via Nrf2-mediated antioxidant induction.Inflammopharmacology · 2026Article
- Curcumin mitigated aflatoxin BJournal of animal science and biotechnology · 2026Article
- Perillaldehyde inhibits oxidative stress, NLRP3-mediated inflammation and fibrosis in diabetic nephropathy through regulating HMOX1.Hereditas · 2026Article
- METTL3-driven mFrontiers in immunology · 2026Article
- The pathogenesis of diabetic kidney disease and the therapeutic potential of bioactive substances.Frontiers in pharmacology · 2025Review
- Dietary and circulating butyrate are independently associated with kidney function in diabetes: a dual-cohort analysis.Frontiers in nutrition · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis study investigates whether curcumin/piperine (C/P) modulates butyrate levels and mitigates diabetic kidney disease (DKD) via the nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling pathway.
methodsEight-week-old mice were treated with C/P for 12 weeks, fecal samples were analyzed for short-chain fatty acids, and inflammatory markers in blood and kidneys were measured. Pathological staining and microscopy assessed the kidney and intestinal tissue morphology. Immunohistochemical detection of the expression of inflammatory markers in the kidneys and intestines.
resultsCurcumin/piperine significantly improved renal injury and intestinal structural integrity, upregulated the expression of macrophage antigen CD68 and other inflammatory markers in the kidneys, and increased NaB levels in feces (
conclusionsCurcumin/piperine enhances renal and intestinal integrity and modulates NaB levels to alleviate DKD through the Nrf2/HO-1 signaling pathway.
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Registered trials
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