ArticleBMC gastroenterology2025
Association between glycated hemoglobin/high-density lipoprotein ratio and nonalcoholic fatty liver disease in a U.S. nondiabetic population: a cross-sectional study based on NHANES 2017-2020 data.
Article in BMC gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- The association between HbA1c/HDL-C ratio and cardiometabolic multimorbidity among middle-aged and older adults: data from two national prospective cohorts in the United Kingdom and United States.Frontiers in nutrition · 2026Article
- Borderline liver enzyme patterns and their metabolic-inflammatory signatures: an observational outpatient study.Frontiers in medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsThe purpose of this research was to explore the relationship between the glycated hemoglobin/high-density lipoprotein (HbA1c/HDL-C) ratio and nonalcoholic fatty liver disease (NAFLD) in non-diabetic adults in the United States.
methodsUsing pertinent variables gathered from the 2017-2020 National Health and Nutrition Examination Survey (NHANES) database, we performed a cross-sectional study including 5,485 adult U.S. citizens. Data were analyzed using multifactor logistic regression, smoothed curve fitting, subgroup, and interaction analyses.
resultsAmong the 5485 individuals included, there was a significant positive correlation between NAFLD and HbA1c/HDL-C ratio. After adjusting for all covariates, the probability of having NAFLD increased significantly for each unit increase in the log-transformed ratio of this [2.39 (1.94, 2.93)]. Furthermore, we discovered a nonlinear relationship with an inflection point of 1.43 between the ratio and NAFLD. In the end, subgroup analyses revealed a significant interaction between the correlation of this ratio and NAFLD, stratified by the presence or absence of comorbid coronary artery disease (interaction P < 0.05).
conclusionOur study demonstrated a significant positive correlation between the HbA1c/HDL-C ratio and NAFLD risk in non-diabetic individuals. Thus, the ratio may be a useful correlate of NAFLD risk. Monitoring this ratio through routine physical examination may help to identify high-risk individuals early and then take lifestyle interventions (e.g., dietary modification, increased exercise, etc.) or pharmacological treatments to prevent the development of NAFLD.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.