Evidence map›Paper›PMID 40775615›Full record

ArticleBMC gastroenterology2025

Predictive factors for metabolic syndrome in patients with metabolic dysfunction-associated steatotic liver disease (MASLD).

Mohammad Alnees, Mahdi Awwad, Duha Najajra, Abdalaziz Darwish, Omar Heih, Thara Al-Ali, Nizar Abu Hamdeh, Ali Abdullah, Jamal Ahmad, Kawthar Jarrar and 4 more

Abstract read
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In one paragraph

Article in BMC gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Mohammad AlneesHead of Palestinian Clinical Research Center, Bethlehem, Palestine. a2011z2012z2013@gmail.com.
Mahdi AwwadPalestinian Clinical Research Center, Bethlehem, Palestine.
Duha NajajraPalestinian Clinical Research Center, Bethlehem, Palestine.
Abdalaziz DarwishPalestinian Clinical Research Center, Bethlehem, Palestine.
Omar HeihPalestinian Clinical Research Center, Bethlehem, Palestine.
Thara Al-AliPalestinian Clinical Research Center, Bethlehem, Palestine.
Nizar Abu HamdehPalestinian Clinical Research Center, Bethlehem, Palestine.
Ali AbdullahInstitute of Gastroenterology and Liver Disease, Kaplan Medical Center, Hebrew University, Rehovot, 76100, Jerusalem, Israel.
Jamal AhmadPalestinian Clinical Research Center, Bethlehem, Palestine.
Kawthar JarrarPalestinian Clinical Research Center, Bethlehem, Palestine.
Alaa Al-IhribatPalestinian Clinical Research Center, Bethlehem, Palestine.
Omar SalloumPalestinian Clinical Research Center, Bethlehem, Palestine.
Qusay AbdohDepartment of Medcial Sciences, Faculty of Medicine & Health Sciences, An-Najah National University, Nablus, Palestine.
Haitham Abu KhadijaKaplan Heart Center, Kaplan Medical Center, Hebrew University, Rehovot, Jerusalem, Israel. haithamab1@clalit.org.il.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMetabolic dysfunction-associated steatotic liver disease (MASLD) is the leading cause of liver disease globally, closely associated with metabolic syndrome.

objectivesThis study aimed to identify significant predictors of metabolic syndrome in patients with MASLD.

methodsA retrospective cross-sectional study was conducted on adult type 2 diabetes mellitus (T2DM) patients between January 2018 and April 2022. Of 314 initially collected patients, those without MASLD or with other liver diseases were excluded, leaving 240 MASLD patients for analysis. Metabolic syndrome was assessed using the NCEP ATP III criteria, and data analysis was performed using Stata17.

resultsHigher systolic blood pressure (adjusted OR = 1.000427, p < 0.0001) and larger waist circumference (adjusted OR = 1.001517, p < 0.0001) were independently associated with increased odds of metabolic syndrome. Additionally, higher triglyceride levels (adjusted OR = 1.064834, p < 0.0001) and lower HDL cholesterol levels (adjusted OR = 0.998595, p = 0.003) were significant predictors. Other variables, including age, HbA1c, BMI, LDL, and hepatic steatosis index, were not significantly associated with metabolic syndrome after adjusting for confounders.

conclusionHigher systolic blood pressure, larger waist circumference, elevated triglyceride levels, and lower HDL cholesterol levels are significant predictors of metabolic syndrome in MASLD patients.

Indexed as

Diabetes Mellitus, Type 2Fatty LiverMetabolic SyndromeAdultAgedBlood PressureCholesterol, HDLCross-Sectional StudiesFemaleHumansMaleMiddle AgedRetrospective StudiesRisk FactorsTriglyceridesWaist CircumferenceCholesterol, HDLTriglyceridesHigh-density lipoproteinMASLDMetabolic dysfunction-associated steatotic liver diseaseMetabolic syndromeSystolic hypertensionTriglycerideWaist circumference

Identifiers

PMID40775615
PMCPMC12329883

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.