ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025
The role of diet in moderating the relationship between symptoms of depression and brain amyloid load.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Living arrangements and cognitive resilience in aging: unraveling distinct pathways through plasma biomarkers.The journal of prevention of Alzheimer's disease · 2026Article
- Association between triglyceride-glucose index-a body shape index and atherosclerotic cardiovascular disease, and the modification effect of dietary patterns.Frontiers in nutrition · 2026Article
- The role of diet in moderating the relationship between symptoms of depression and brain amyloid load.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
backgroundHealthy lifestyle factors, including diet, may affect brain amyloid beta (Aβ) load. This study examines dietary patterns as moderators of the relationships among symptoms of depression, anxiety, and brain Aβ load.
methodA cross-sectional study of cognitively unimpaired older adults (n = 524) from the Australian Imaging, Biomarkers, and Lifestyle study assessed dietary patterns, depressive and anxiety symptoms, and brain Aβ load. Moderation and simple slope analyses were conducted.
resultsThe Dietary Approaches to Stop Hypertension (DASH) diet moderated the relationship between depressive and anxiety symptoms and brain Aβ load. Higher symptoms were associated with greater Aβ load in individuals with lower DASH adherence. This effect was also observed for anxiety symptoms in apolipoprotein E ε4 carriers. The Mediterranean and Western diets did not moderate these relationships.
conclusionThe DASH diet adherence may mitigate the impact of depressive and anxiety symptoms on brain Aβ load, supporting genotype-specific dietary interventions in mental and brain health. HIGHLIGHTS: The Dietary Approaches to Stop Hypertension (DASH) diet moderates the links among depression, anxiety, and brain amyloid load. Higher symptoms were linked to greater amyloid load in those with low DASH adherence. This effect was observed for anxiety symptoms in apolipoprotein E ε4 allele carriers. Mediterranean and Western diets did not moderate these relationships. Findings support genotype-specific dietary interventions for brain and mental health.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.