ArticleJournal of orthopaedic surgery and research2025
Association between lncRNA H19 and osteoporosis in postmenopausal patients with type 2 diabetes mellitus.
Article in Journal of orthopaedic surgery and research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Bone Healing Around Implants in Normal and Medically Compromised Conditions: Osteoporosis and Diabetes.Advanced healthcare materials · 2026Review
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6 authors.
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Abstract
backgroundThis study aimed to assess the expression level of long non-coding RNA H19 (lncRNA H19) in peripheral blood mononuclear cells (PBMCs) of postmenopausal patients with type 2 diabetes mellitus (T2DM) with comorbid osteoporosis (T2DM-OP), and to evaluate its diagnostic value and its role in the pathogenesis of T2DM-OP.
methodsA total of 150 postmenopausal patients with T2DM were recruited from the First People's Hospital of Lianyungang City, China. Based on the bone mineral density (BMD) results measured by dual-energy X-ray absorptiometry (DXA), the patients were stratified into the T2DM-OP group (n = 108) and the T2DM group (n = 42). Clinical data and laboratory parameters were collected, and quantitative reverse transcription polymerase chain reaction (qRT-PCR) was used to quantitatively determine the expression of lncRNA H19 in PBMCs.
resultsWhen compared with the T2DM group, the expression level of lncRNA H19 in PBMCs of T2DM-OP patients was significantly lower (P < 0.001). The results of bivariate analysis revealed that lncRNA H19 was positively correlated with albumin (ALB, R = 0.311) and BMD (R = 0.696), while negatively correlated with age (R = -0.514), glycated hemoglobin A1c (HbA1c, R = -0.272), fasting blood glucose (FBG, R = -0.275), and transforming growth factor-β1 (TGF-β1, R = -0.392). All of these correlations were statistically significant (R < 0.001). Binary logistic regression analysis identified age, body mass index (BMI), HbA1c, TGF-β1, and lncRNA H19 as independent risk factors for T2DM-OP. Additionally, multiple linear regression analysis demonstrated that age, HbA1c, FBG, TGF-β1, and BMD were key determinants of the expression of lncRNA H19. Receiver operating characteristic (ROC) curve analysis indicated that lncRNA H19 had high diagnostic accuracy for postmenopausal T2DM-OP, with an area under the curve (AUC) of 0.833.
conclusionsThe expression level of lncRNA H19 in PBMCs of postmenopausal T2DM-OP patients was significantly reduced. This reduction could contribute to the pathogenesis of T2DM-OP through the regulation of modulating glucose metabolism and the lncRNA H19/TGF-β1 signaling pathway. Moreover, its expression level may serve as a highly promising non-invasive biomarker with high diagnostic accuracy for the early detection of postmenopausal T2DM-OP.
trial registrationRetrospectively registered (ChiCTR2300074807).
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