Evidence map›Paper›PMID 40775726›Full record

ArticleGenome biology2025

Oatk: a de novo assembly tool for complex plant organelle genomes.

Chenxi Zhou, Max Brown, Mark Blaxter, Darwin Tree of Life Project Consortium, Shane A McCarthy, Richard Durbin

Abstract read
In one paragraph

Article in Genome biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 121 papers.

0numbers the graph read from it
0cells of the map it votes in
121citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

121 citing papers in PubMed.

  1. Near-complete genomes for nine haplochromine cichlid fishes reveal a novel centromeric satellite structure organised around a pair of inverted elements.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2026
    Article
  2. Article
  3. Article
  4. TheGenes · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. A Compact Multipartite Mitogenome ofInternational journal of molecular sciences · 2026
    Article
  9. Chromosomal evolution and speciation inferred from chromosome-scale genome assemblies in three Cupressaceae species.DNA research : an international journal for rapid publication of reports on genes and genomes · 2026
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

61 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chenxi ZhouDepartment of Genetics, University of Cambridge, Downing Street, Cambridge, CB2 3EH, UK.
Max BrownWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.
Mark BlaxterWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.
Darwin Tree of Life Project Consortium
Shane A McCarthyDepartment of Genetics, University of Cambridge, Downing Street, Cambridge, CB2 3EH, UK.
Richard DurbinDepartment of Genetics, University of Cambridge, Downing Street, Cambridge, CB2 3EH, UK. rd109@cam.ac.uk.

Funding

Wellcome TrustWellcome Trust 207492Wellcome Trust 218328Wellcome Trust 220540
6 · The paper itself

Abstract

Plant organelle genomes, particularly large mitochondrial genomes with complex repeats, present significant challenges for assembly. The advent of long-read sequencing enables the assembly of complete genomes, but problems of resolving alternative structures remain. Here we introduce a novel tool that employs a syncmer-based assembler for rapid assembly graph construction, integrates a profile-HMM database for robust organelle identification, and leverages a new search method to find the best supported path through the assembly graph. We describe high-quality organelle assemblies for 195 plant species, demonstrating improvements over other methods, and providing multiple insights into structural complexity, heteroplasmy, and DNA exchange between organelles.

Indexed as

Genome, MitochondrialGenome, PlantSoftwareOrganellesAssembly graphGenome assemblyMitogenomeOrganelle genomePlastomeSyncmer

Identifiers

PMID40775726
PMCPMC12329965

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.