Evidence map›Paper›PMID 40775760›Full record

ArticleBMC biology2025

CRL2

Bing Jiang, Kehan Wang, Haoyue Hu, Wenxin Gao, Cong Shen, Xia Chen, Xiaoyan Huang, Jun Yu, Yibo Wu, Bo Zheng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. WSB1 is dispensable for mouse spermatogenesis and male fertility.American journal of translational research · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Bing Jiang *Human Reproductive and Genetic Center, Affiliated Hospital of Jiangnan University, Wuxi, 214062, China.
Kehan Wang *State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproduction and Genetics, Gusu School, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Nanjing Medical University, Suzhou, 215002, China.
Haoyue Hu *Human Reproductive and Genetic Center, Affiliated Hospital of Jiangnan University, Wuxi, 214062, China.
Wenxin GaoState Key Laboratory of Reproductive Medicine and Offspring Health, Department of Histology and Embryology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, 211166, China.
Cong ShenState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproduction and Genetics, Gusu School, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Nanjing Medical University, Suzhou, 215002, China.
Xia ChenCenter of Reproductive Medicine, Department of Obstetrics and Gynecology, Affiliated Hospital of Nantong University, Nantong, 226001, China.
Xiaoyan HuangState Key Laboratory of Reproductive Medicine and Offspring Health, Department of Histology and Embryology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, 211166, China. bbhxy@njmu.edu.cn.
Jun YuInstitute of Reproductive Medicine, Medical School of Nantong University, Nantong University, Nantong, 226001, China. yujun9117@ntu.edu.cn.
Yibo WuHuman Reproductive and Genetic Center, Affiliated Hospital of Jiangnan University, Wuxi, 214062, China. moliaty@aliyun.com.
Bo ZhengState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproduction and Genetics, Gusu School, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Nanjing Medical University, Suzhou, 215002, China. bozheng@njmu.edu.cn.

Funding

National Natural Science Foundation of China 32370903National Natural Science Foundation of China 32470899National Natural Science Foundation of China 82271633
6 · The paper itself

Abstract

backgroundHuman spermatogonial stem cells (SSCs) exhibit a remarkable capacity for proliferation, crucial for sustaining spermatogenesis throughout life. While the Cullin-RING E3 ubiquitin ligase 2 (CRL2) complex is known to regulate various cellular functions, its precise role in human SSCs has not been fully elucidated. This study aimed to investigate a novel variant of the CRL2 complex, termed CRL2

methodsWe utilized molecular biology techniques, including gene knockdown and functional assays, to assess the effects of CRL2

resultsOur findings revealed that the disruption or dysfunction of CRL2

conclusionsThis study provides the first identification of the CRL2

Indexed as

Adult Germline Stem CellsCell MovementCell ProliferationDEAD-box RNA HelicasesELAV-Like Protein 1RNA StabilitySpermatogoniaUbiquitinationUbiquitin-Protein LigasesCell LineHumansMaleDdx5 protein, humanDEAD-box RNA HelicasesELAVL1 protein, humanELAV-Like Protein 1Ubiquitin-Protein LigasesDDX5ELAVL1LRRC41Spermatogonial Stem CellsUbiquitination

Identifiers

PMID40775760
PMCPMC12329934

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.