Evidence map›Paper›PMID 40776396›Full record

Trial reportPsychological medicine2025

Diazepam modulates hippocampal CA1 functional connectivity in people at clinical high-risk for psychosis.

Nicholas R Livingston, Amanda Kiemes, Owen O'Daly, Samuel R Knight, Paulina B Lukow, Luke A Jelen, Thomas J Reilly, Aikaterini Dima, Maria A Nettis, Cecilia Casetta and 10 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Psychological medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Nicholas R LivingstonDepartment of Psychological Medicine, https://ror.org/0220mzb33Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.ORCID 0000-0002-6582-2545
Amanda KiemesDepartment of Psychological Medicine, https://ror.org/0220mzb33Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.
Owen O'DalyDepartment of Neuroimaging, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.
Samuel R KnightDepartment of Psychological Medicine, https://ror.org/0220mzb33Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.
Paulina B LukowInstitute of Cognitive Neuroscience, University College London, London, UK.
Luke A JelenDepartment of Psychological Medicine, https://ror.org/0220mzb33Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.
Thomas J ReillyDepartment of Psychiatry, https://ror.org/052gg0110University of Oxford, Oxford, UK.
Aikaterini DimaDepartment of Psychosis Studies, Institute of Psychiatry, Psychology, and Neuroscience, https://ror.org/0220mzb33King's College London, London, UK.
Maria A NettisDepartment of Psychosis Studies, Institute of Psychiatry, Psychology, and Neuroscience, https://ror.org/0220mzb33King's College London, London, UK.
Cecilia CasettaDepartment of Psychosis Studies, Institute of Psychiatry, Psychology, and Neuroscience, https://ror.org/0220mzb33King's College London, London, UK.
Gabriel A DevenyiDepartment of Psychiatry, https://ror.org/01pxwe438McGill University, Montreal, QC, Canada.
Thomas SpencerDepartment of Psychosis Studies, Institute of Psychiatry, Psychology, and Neuroscience, https://ror.org/0220mzb33King's College London, London, UK.
Andrea De MicheliOutreach and Support in South-London (OASIS) Service, South London and Maudsley National Health Service Foundation Trust, London, UK.
Paolo Fusar-PoliOutreach and Support in South-London (OASIS) Service, South London and Maudsley National Health Service Foundation Trust, London, UK.
Anthony A GraceDepartments of Neuroscience, Psychiatry and Psychology, https://ror.org/01an3r305University of Pittsburgh, Pittsburgh, PA, USA.
Steve C R WilliamsDepartment of Neuroimaging, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.
Philip McGuireDepartment of Psychiatry, https://ror.org/052gg0110University of Oxford, Oxford, UK.
M Mallar ChakravartyDepartment of Psychiatry, https://ror.org/01pxwe438McGill University, Montreal, QC, Canada.
Alice EgertonDepartment of Psychosis Studies, Institute of Psychiatry, Psychology, and Neuroscience, https://ror.org/0220mzb33King's College London, London, UK.
Gemma ModinosDepartment of Psychological Medicine, https://ror.org/0220mzb33Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.

Funding

Gating of Information Flow Within the Nucleus Accumbens (Supplement)R01MH057440 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ANTHONY A GRACE · 1997 to 2026
$7.2M
NIMH NIH HHS R01 MH057440Royal Society 202397/Z/16/ZWellcome TrustWellcome Trust 202397/Z/16/Z
6 · The paper itself

Abstract

backgroundPreclinical evidence suggests that diazepam enhances hippocampal γ-aminobutyric acid (GABA) signalling and normalises a psychosis-relevant cortico-limbic-striatal circuit. Hippocampal network dysconnectivity, particularly from the CA1 subfield, is evident in people at clinical high-risk for psychosis (CHR-P), representing a potential treatment target. This study aimed to forward-translate this preclinical evidence.

methodsIn this randomised, double-blind, placebo-controlled study, 18 CHR-P individuals underwent resting-state functional magnetic resonance imaging twice, once following a 5 mg dose of diazepam and once following a placebo. They were compared to 20 healthy controls (HC) who did not receive diazepam/placebo. Functional connectivity (FC) between the hippocampal CA1 subfield and the nucleus accumbens (NAc), amygdala, and ventromedial prefrontal cortex (vmPFC) was calculated. Mixed-effects models investigated the effect of group (CHR-P placebo/diazepam vs. HC) and condition (CHR-P diazepam vs. placebo) on CA1-to-region FC.

resultsIn the placebo condition, CHR-P individuals showed significantly lower CA1-vmPFC (

conclusionsThis study demonstrates that diazepam can partially restore hippocampal CA1 dysconnectivity in CHR-P individuals, suggesting that modulation of GABAergic function might be useful in the treatment of this clinical group.

Indexed as

CA1 Region, HippocampalDiazepamPrefrontal CortexPsychotic DisordersAdultAmygdalaDouble-Blind MethodFemaleHumansMagnetic Resonance ImagingMaleNucleus AccumbensYoung AdultDiazepambenzodiazepineearly interventionneuroimagingpharmacological MRIresting-stateschizophrenia

Identifiers

PMID40776396
PMCPMC12360692

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.