Evidence map›Paper›PMID 40776752›Full record

ArticleMolecular medicine reports2025

Deciphering age‑related differences in wound healing: Insights from the interaction between endothelial cells and fibroblasts.

Jianjun Li, Dongzhen Zhu, Mengde Zhang, Zhao Li, Liting Liang, Yuyan Huang, Xu Guo, Yi Kong, Xiaobing Fu, Sha Huang

Abstract read
In one paragraph

Article in Molecular medicine reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jianjun Li *Research Center for Tissue Repair and Regeneration Affiliated to the Medical Innovation Research Department, PLA General Hospital and PLA Medical College, PLA Key Laboratory of Tissue Repair and Regenerative Medicine, Beijing 100853, P.R. China.
Dongzhen Zhu *Research Center for Tissue Repair and Regeneration Affiliated to the Medical Innovation Research Department, PLA General Hospital and PLA Medical College, PLA Key Laboratory of Tissue Repair and Regenerative Medicine, Beijing 100853, P.R. China.
Mengde ZhangResearch Center for Tissue Repair and Regeneration Affiliated to the Medical Innovation Research Department, PLA General Hospital and PLA Medical College, PLA Key Laboratory of Tissue Repair and Regenerative Medicine, Beijing 100853, P.R. China.
Zhao LiResearch Center for Tissue Repair and Regeneration Affiliated to the Medical Innovation Research Department, PLA General Hospital and PLA Medical College, PLA Key Laboratory of Tissue Repair and Regenerative Medicine, Beijing 100853, P.R. China.
Liting LiangResearch Center for Tissue Repair and Regeneration Affiliated to the Medical Innovation Research Department, PLA General Hospital and PLA Medical College, PLA Key Laboratory of Tissue Repair and Regenerative Medicine, Beijing 100853, P.R. China.
Yuyan HuangResearch Center for Tissue Repair and Regeneration Affiliated to the Medical Innovation Research Department, PLA General Hospital and PLA Medical College, PLA Key Laboratory of Tissue Repair and Regenerative Medicine, Beijing 100853, P.R. China.
Xu GuoCollege of Graduate, Tianjin Medical University, Tianjin 300050 P.R. China.
Yi KongResearch Center for Tissue Repair and Regeneration Affiliated to the Medical Innovation Research Department, PLA General Hospital and PLA Medical College, PLA Key Laboratory of Tissue Repair and Regenerative Medicine, Beijing 100853, P.R. China.
Xiaobing FuResearch Center for Tissue Repair and Regeneration Affiliated to the Medical Innovation Research Department, PLA General Hospital and PLA Medical College, PLA Key Laboratory of Tissue Repair and Regenerative Medicine, Beijing 100853, P.R. China.
Sha HuangResearch Center for Tissue Repair and Regeneration Affiliated to the Medical Innovation Research Department, PLA General Hospital and PLA Medical College, PLA Key Laboratory of Tissue Repair and Regenerative Medicine, Beijing 100853, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aging impairs wound healing, primarily because of alterations in cell phenotypes and interactions, particularly between endothelial cells (ECs) and fibroblasts (Fibs). The present study investigated the dynamics of EC‑Fib interactions in aged wounds using a mouse model and single‑cell transcriptomics, supplemented by CellChat analysis and functional validation using

Indexed as

AgingCell CommunicationEndothelial CellsFibroblastsWound HealingAnimalsCoculture TechniquesDisease Models, AnimalGene Expression ProfilingHumansMaleMiceMice, Inbred C57BLNeovascularization, PhysiologicTranscriptomeTransforming Growth Factor betaTransforming Growth Factor betaaged woundcell‑cell communicationsingle‑cell RNA‑seqTGF‑βvascularization

Identifiers

PMID40776752
PMCPMC12340756

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.