Evidence map›Paper›PMID 40776916›Full record

ArticleFrontiers in medicine2025

Pro-inflammatory markers as predictors of arterial thrombosis in aged patients with peripheral arterial disease post revascularization.

Adriana A Rodriguez Alvarez, Isabella F Cieri, Mounika Naidu Boya, Shiv Patel, Aniket Agrawal, Sasha P Suarez Ferreira, Christianah Alli, Shruti Sharma, Anahita Dua

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Adriana A Rodriguez Alvarez *Division of Vascular and Endovascular Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
Isabella F Cieri *Division of Vascular and Endovascular Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
Mounika Naidu BoyaDivision of Vascular and Endovascular Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
Shiv PatelDivision of Vascular and Endovascular Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
Aniket AgrawalDivision of Vascular and Endovascular Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
Sasha P Suarez FerreiraDivision of Vascular and Endovascular Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
Christianah AlliDivision of Vascular and Endovascular Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
Shruti SharmaDepartment of Immunology, Tufts University School of Medicine, Boston, MA, United States.
Anahita DuaDivision of Vascular and Endovascular Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.

Funding

Intracellular nucleic acid sensing and age-related chronic inflammationR01AI142005 · NIAID · TUFTS UNIVERSITY BOSTON · PI SHARMA, SHRUTI · 2019 to 2023
$2.3M
NIAID NIH HHS R01 AI142005
6 · The paper itself

Abstract

Introduction: Inflammation occurs in the initial stage of arterial atherosclerosis and serves as the first step in thrombus generation, with elevated inflammatory markers predicting myocardial infarction in coronary artery disease patients. Inflammation is known to alter the course of multiple diseases and can thus, also impact recovery post-treatment and surgical outcomes. Yet, there is a paucity of data regarding the relationship between inflammatory biomarkers and arterial thrombotic potential in peripheral artery disease (PAD) patients post-revascularization. Our pilot study attempts to fill this gap by evaluating if the expression of inflammatory biomarkers in PAD patients correlates with the incidence of thrombotic events post-revascularization. Methods: Plasma samples were prospectively collected from PAD patients who underwent revascularization from 2021 to 2023 at monthly time points for 6 months from the procedure. Patients were followed for a total of 6 months post-procedure and those who experienced thrombotic events were identified. Nine patients with thrombotic events and 16 with non-thrombotic events along with 5 healthy volunteers were analyzed. Plasma samples were analyzed for the following pro-inflammatory markers: IL-1β (Interleukin-1 beta), IL-6, and TNF- Results: A total of 303 patients were enrolled, of which 59 had thrombotic events. There were no differences between medications or disease burden between groups. Levels of circulating IL-6 and TNF- Conclusion: Pro-inflammatory markers IL-6 and TNF-

Indexed as

inflammationinterleukin-6peripheral artery disease (PAD)thrombosistumor necrosis factor-alpha

Identifiers

PMID40776916
PMCPMC12328425

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.