ReviewReviews in cardiovascular medicine2025
Programmed Cell Death in Heart Failure: Mechanisms, Impacts, and Therapeutic Prospects.
Review in Reviews in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Dapagliflozin alleviates heart failure with preserved ejection fraction potentially by regulating the AIM2/caspase‑1/GSDMD pathway and attenuating pyroptosis.Molecular medicine reports · 2026Article
- Melatonin Attenuates Glucolipotoxicity-Induced Cardiac Oxidative Stress, Inflammation, Pyroptosis, and Fibrotic Remodeling in STZ/HFD-Treated ApoEAntioxidants (Basel, Switzerland) · 2026Article
- The Influence of Basic Therapy and New Drugs on NO-Dependent Mechanisms of Cardiac Destruction in Chronic Heart Failure.Biomedicines · 2026Review
- Desidustat's cardioprotective mechanisms in heart failure: a network pharmacology, molecular docking and dynamics approach.Scientific reports · 2026Article
- MicroRNAs in Heart Failure Pathogenesis and Progression: Mechanistic Control, Biomarker Potential, and Translational Perspectives.Life (Basel, Switzerland) · 2026Review
- An Integrated Model of Biphasic Apoptosis in Avian Coccidiosis: Molecular Networks and Host-Parasite Interplay.Animals : an open access journal from MDPI · 2025Review
- Integrative Machine Learning Analysis of Programmed Cell Death Pathways Identifies Novel Diagnostic Biomarkers for Atrial Fibrillation.Journal of inflammation research · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heart failure is a complex pathological condition characterized by various mechanisms of cellular death, among which programmed cell death (PCD) plays a crucial role in the pathophysiology of cardiac dysfunction. This review delves into the different forms of PCD present in heart failure, including apoptosis, autophagy, necroptosis, pyroptosis, and ferroptosis, and examines the mechanisms of action involved and the potential therapeutic targets for treating cardiac failure. By analyzing the latest research findings, we reveal the pivotal role of PCD in the progression of heart failure and discuss the preclinical prospects of intervening in these processes to develop novel therapeutic strategies. For instance, pharmacological agents that inhibit receptor-interacting protein kinases (RIPK1 and RIPK3) involved in necroptosis have been demonstrated to reduce cardiac injury and improve functional outcomes. Additionally, targeting the inflammatory responses associated with necrotic cell death, such as using interleukin (IL)-1β inhibitors, may provide a dual benefit by reducing cell death and inflammation. Thus, combining current knowledge will enhance our understanding in this field and promote innovative approaches to managing heart failure more effectively.
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Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.