ArticleFrontiers in oncology2025
Decoding colorectal cancer lung metastasis: a global research odyssey.
Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Colorectal cancer (CRC) remains a major global health burden, particularly when complicated by pulmonary metastasis (PM), which significantly worsens prognosis and reduces survival despite active treatment. The absence of standardized therapeutic strategies for CRC with PM has driven research into its underlying biological mechanisms, including epithelial-mesenchymal transition, immune evasion, and tumor microenvironment dynamics. Methods: A bibliometric analysis was conducted on 2,645 publications related to CRC with PM retrieved from the Web of Science Core Collection (1991-2025). Analytical tools such as CiteSpace and VOSviewer were employed to map the intellectual structure, collaboration networks, and research hotspots within this domain. Results: The analysis identified China and Japan as the most prolific countries in CRC-PM research, with Robert M. Hoffman (USA) and David L. Morris (Australia) as the most productive authors, and Joachim Pfannschmidt (Germany) as the most frequently cited. Annals of Surgery was recognized as the most influential journal. Four primary research themes were identified: (1) molecular mechanisms underlying CRC lung metastasis, (2) surgical intervention strategies, (3) systemic therapies and clinical trials, and (4) clinical management and outcome evaluation. These studies reflect a growing emphasis on multidisciplinary approaches and translational research. Conclusion: The field has witnessed notable progress in multimodal treatment strategies, encompassing advances in surgical techniques, chemotherapy regimens, and targeted therapies, all of which have contributed to improved patient assessment and survival outcomes. Future research should focus on optimizing integrated therapeutic approaches and refining clinical management protocols to further improve outcomes for patients with CRC and pulmonary metastases.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.