Evidence map›Paper›PMID 40777243›Full record

ArticlebioRxiv : the preprint server for biology2025

Genetic Modulation of Lifespan: Dynamic Effects, Sex Differences, and Body Weight Trade-offs.

Danny Arends, David G Ashbrook, Suheeta Roy, Lu Lu, Zachary Sloan, Arthur G Centeno, Kurt H Lamour, João Pedro de Magalhães, Pjotr Prins, Karl W Broman and 14 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors.

Danny ArendsDepartment of Applied Sciences, Northumbria University, Newcastle upon Tyne, UK.
David G AshbrookDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center; Memphis, TN, USA.
Suheeta RoyDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center; Memphis, TN, USA.
Lu LuDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center; Memphis, TN, USA.
Zachary SloanDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center; Memphis, TN, USA.
Arthur G CentenoDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center; Memphis, TN, USA.
Kurt H LamourDepartment of Entomology and Plant Pathology, The University of Tennessee, Knoxville, Knoxville, TN, USA.
João Pedro de MagalhãesDepartment of Inflammation and Ageing, University of Birmingham, Birmingham, UK.ORCID 0000-0002-6363-2465
Pjotr PrinsDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center; Memphis, TN, USA.
Karl W BromanDepartment of Biostatistics and Medical Informatics, University of Wisconsin-Madison; Madison, WI, USA.ORCID 0000-0002-4914-6671
Saunak SenDepartment of Preventive Medicine, University of Tennessee Health Science Center; Memphis, TN, USA.ORCID 0000-0003-4519-6361
Sarah J MitchellLudwig Princeton Branch, Princeton University; Princeton, NJ, USA.
Michael R MacArthurLewis-Sigler Institute for Integrative Genomics, Princeton University; Princeton, NJ, USA.
Özlem Altintas AkinDepartment of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland.
Johan AuwerxLaboratory of Integrative Systems Physiology, Institute of Bioengineering, École Polytechnique Fédérale de Lausanne; Lausanne, Switzerland.
Amandeep BajwaDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center; Memphis, TN, USA.
Vivian DiazBarshop Institute for Longevity and Aging Studies, University of Texas Health San Antonio; San Antonio USA.
David E HarrisonThe Jackson Laboratory; Bar Harbor, ME, USA.
Randy StrongBarshop Institute for Longevity and Aging Studies, University of Texas Health San Antonio; San Antonio USA.
James F NelsonBarshop Institute for Longevity and Aging Studies, University of Texas Health San Antonio; San Antonio USA.
Khyobeni MozhuiDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center; Memphis, TN, USA.
Evan G WilliamsLuxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg.ORCID 0000-0002-9746-376X
Richard A MillerDepartment of Pathology and Geriatrics Center, University of Michigan, Ann Arbor, MI 48109, USA.
Robert W WilliamsDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center; Memphis, TN, USA.ORCID 0000-0001-8924-4447

Funding

TRANSGENIC COREP30AG013319 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI RANDY STRONG, Adam Salmon · 1995 to 2026
$30.6M
Interventions That Retard Mammalian AgingU01AG022308 · NIA · JACKSON LABORATORY · PI Ronny Korstanje · 2003 to 2026
$30.5M
Research Education CoreP30AG024824 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Lona Mody, RAYMOND L YUNG · 2004 to 2026
$29.2M
Center for Testing Potential Anti-Aging InterventionsU01AG022307 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI RANDY STRONG, Adam Salmon · 2004 to 2026
$26.3M
Laboratory for Anti-Geric Testing, Evaluation and ResearchU01AG022303 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI RICHARD A MILLER · 2003 to 2026
$25.4M
Imaging Genetics of Brain Structure and Cognitive Aging in Murine Models of Alzheimer's DiseaseR01AG070913 · NIA · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI JOHNSON, GEORGE ALLAN, WILLIAMS, ROBERT W. · 2021 to 2025
$6.1M
Shock Center for Aging Research at The Jackson Laborato*P30AG025707 · NIA · JACKSON LABORATORY · PI WOYCHIK, RICHARD P · 2005 to 2009
$4.1M
TIM Project NIDA P30 CenterP30DA044223 · NIDA · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI WILLIAMS, ROBERT W. · 2017 to 2021
$3.9M
A Unified High Performance Web Service for Systems Genetics and Precision MedicineR01GM123489 · NIGMS · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI PRINS, PJOTR, SEN, SAUNAK · 2017 to 2024
$3.7M
The interaction effects of genetic variants, age, diet, sex and mitochondrial copy number on Alzheimer's disease, aging-phenotypes and longevityR01AG075813 · NIA · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI David George Ashbrook · 2022 to 2026
$2.8M
Translational Systems Genetics of Mitochondria, Metabolism, and AgingR01AG043930 · NIA · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI WILLIAMS, ROBERT W. · 2013 to 2017
$2.5M
DNA methylation and gene expression study of aging and lifespan differencesR21AG055841 · NIA · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI MOZHUI, KHYOBENI · 2017 to 2018
$418k
NIA NIH HHS P30 AG013319NIA NIH HHS P30 AG024824NIA NIH HHS P30 AG025707NIA NIH HHS R01 AG043930NIA NIH HHS R01 AG070913NIA NIH HHS R01 AG075813NIA NIH HHS R21 AG055841NIA NIH HHS R56 AG066625NIA NIH HHS U01 AG022303NIA NIH HHS U01 AG022307NIA NIH HHS U01 AG022308NIDA NIH HHS P30 DA044223NIGMS NIH HHS R01 GM123489
6 · The paper itself

Abstract

The dynamics of lifespan are shaped by DNA variants that exert effects at different ages. We have mapped genetic loci that modulate age-specific mortality using an actuarial approach. We started with an initial population of 6,438 pubescent siblings and ended with a survivorship of 559 mice that lived to at least 1100 days. Twenty-nine

Identifiers

PMID40777243
PMCPMC12330653

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.