Evidence map›Paper›PMID 40777323›Full record

ArticlebioRxiv : the preprint server for biology2025

Calyculin A Induces Premature Chromosome Condensation and Chromatin Compaction in G

Natalia Y Kochanova, Matthieu Vermeren, Bram Prevo, Ipek Ustun, Shaun Webb, Linfeng Xie, William C Earnshaw, James R Paulson

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Natalia Y KochanovaWellcome Trust Centre for Cell Biology, Institute for Cell and Molecular Biology, University of Edinburgh, Swann Building, King's Buildings, Mayfield Road, Edinburgh, EH9 3JR U.K.ORCID 0000-0001-9951-8333
Matthieu VermerenInstitute for Regeneration and Repair, University of Edinburgh, 5 Little France Dr, Edinburgh, EH16 4UU U.K.ORCID 0000-0003-3584-0387
Bram PrevoWellcome Trust Centre for Cell Biology, Institute for Cell and Molecular Biology, University of Edinburgh, Swann Building, King's Buildings, Mayfield Road, Edinburgh, EH9 3JR U.K.ORCID 0000-0002-6526-5590
Ipek UstunWellcome Trust Centre for Cell Biology, Institute for Cell and Molecular Biology, University of Edinburgh, Swann Building, King's Buildings, Mayfield Road, Edinburgh, EH9 3JR U.K.
Shaun WebbSchool of Biological Sciences, Darwin Building, King's Buildings, Mayfield Road, Edinburgh, EH9 3JR U.K.ORCID 0000-0002-4956-3766
Linfeng XieDepartment of Chemistry, University of Wisconsin-Oshkosh, 800 Algoma Blvd, Oshkosh, WI 54901 U.S.A.ORCID 0000-0002-7025-2671
William C EarnshawWellcome Trust Centre for Cell Biology, Institute for Cell and Molecular Biology, University of Edinburgh, Swann Building, King's Buildings, Mayfield Road, Edinburgh, EH9 3JR U.K.ORCID 0000-0002-7191-0621
James R PaulsonDepartment of Chemistry, University of Wisconsin-Oshkosh, 800 Algoma Blvd, Oshkosh, WI 54901 U.S.A.ORCID 0000-0003-1262-1560

Funding

Role of Proteases in Therapy-Induced ApoptosisR01CA069008 · NCI · MAYO CLINIC ROCHESTER · PI KAUFMANN, SCOTT H · 1995 to 2010
$3.4M
NCI NIH HHS R01 CA069008Wellcome Trust
6 · The paper itself

Abstract

We show here that treatment of HeLa cells with calyculin A, an inhibitor of Protein Phosphatases 1 and 2A, induces premature chromosome condensation (PCC) at any point in interphase of the cell cycle. Chromosomes in G

Identifiers

PMID40777323
PMCPMC12330644

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.