ArticleCureus2025
A Rare Case of Human Herpesvirus 6 Meningitis in an Immunocompetent Adult Presenting With Recurrent Encephalopathy: Could Prior Head Trauma or an Incidental Cerebral Cavernous Malformation Be a Predisposing Factor?
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human herpesvirus 6 (HHV-6) meningitis/encephalitis is typically seen in immunocompromised patients, with rare reports in immunocompetent adults. We present the case of a 52-year-old immunocompetent man with recurrent acute encephalopathy and incidental cerebral cavernous malformation (CCM), alongside a remote history of traumatic brain injury (TBI). Cerebrospinal fluid (CSF) analysis and multiplex polymerase chain reaction (PCR) test confirmed HHV-6 infection, with neuroimaging showing leptomeningeal enhancement. This case suggests that structural brain abnormalities such as CCM and prior TBI may cause chronic blood-brain barrier (BBB) disruption, facilitating HHV-6 neuroinvasion even in the absence of immunosuppression. Awareness of such predisposing factors is crucial for the timely diagnosis and treatment of HHV-6 meningitis/encephalitis in immunocompetent individuals. Further research is needed to clarify the pathophysiological link between BBB dysfunction and HHV-6 central nervous system (CNS) infection.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.