ArticleCureus2025
Sustained Effects of Glucagon-Like Peptide-1 (GLP-1) Agonists on Blood Pressure in Obesity and Type 2 Diabetes: A Longitudinal Case Study.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) confer multiple cardiometabolic benefits beyond glycemic control, including weight reduction and potential cardiovascular protection. This case presents an 18-month follow-up of a 48-year-old obese male with type 2 diabetes mellitus (T2DM) and hypertension, who achieved sustained blood pressure (BP) control and lipid stability on semaglutide following discontinuation of triple antihypertensive therapy. At baseline, the patient had a BMI of 38 kg/m², BP of 156/96 mmHg, and an elevated glycosylated hemoglobin (HbA1c). Semaglutide was initiated at 0.25 mg weekly and titrated to 1 mg over six months. The patient exhibited progressive improvements in glycemic control, body weight, and BP, with HbA1c reduction and weight loss sustained over 18 months. Notably, BP remained consistently ≤130/80 mmHg, and lipid parameters remained stable without additional pharmacotherapy. This case underscores the potential of GLP-1 RAs to exert antihypertensive effects, possibly through weight loss, vascular endothelial function enhancement, and modulation of the renin-angiotensin-aldosterone system (RAAS). These findings support the evolving role of GLP-1 RAs as a multifaceted therapeutic option in managing T2DM with coexisting cardiovascular risk factors.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.