Evidence map›Paper›PMID 40777747›Full record

Review3 Biotech2025

Bridging the molecular and clinical aspects of resveratrol in Alzheimer's disease: a review.

Liju Susan Mathew, Aradhana Marathe, Akash Aman, Anmol Vats, Teresa Joy, Y Lakshmisha Rao

Abstract readReview
In one paragraph

Review in 3 Biotech, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Liju Susan MathewDepartment of Biomedical Sciences, College of Medicine, Gulf Medical University, Ajman, United Arab Emirates.ORCID 0000-0001-8664-3442
Aradhana MaratheDepartment of Biochemistry, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Manipal, India.ORCID 0000-0002-4745-1162
Akash AmanKasturba Medical College Mangalore, Manipal Academy of Higher Education, Manipal, India.
Anmol VatsKasturba Medical College Mangalore, Manipal Academy of Higher Education, Manipal, India.
Teresa JoyDepartment of Anatomy and Medical Imaging, American University of Antigua College of Medicine, Antigua, WI USA.ORCID 0000-0003-1834-8606
Y Lakshmisha RaoDepartment of Anatomy, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Manipal, India.ORCID 0000-0002-9951-1606

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is a progressive brain disorder that affects neurological functioning specifically targeting cognition, memory and behaviour. Pathology starts with the accumulation of tau proteins which on phosphorylation can be destructive for brain function. With gold standard drugs like Donepezil, there have been several attempts made to discover adjuvant therapeutic molecules such as plant-based products that could not only ease the ill-toward effects of these drugs, but also lead to the betterment of the patients suffering from AD. These are crucial in the management of patients of AD, by associations with psychological vulnerabilities and the overall loss of health of such individuals 'Resveratrol' is one such plant-based molecule which is a stilbene polyphenol present in many of the commonly occurring plants. Resveratrol is reported to have anti-oxidant and anti-inflammatory properties which brings about the neuroprotection. Several studies have also been conducted that targets the signalling cascades involved during the progression of AD. This review attempts to give a collective information of its properties, its synthesis, metabolism and mechanisms that could drive researchers forward for its therapeutic applications during the treatment of Alzheimer's disease.

Indexed as

Alzheimer’s diseaseAnti-inflammatoryAnti-oxidantNeurodegenerationNeuroprotectiveResveratrol

Identifiers

PMID40777747
PMCPMC12328867

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.