Programmable DNA-based biomaterials for bone tissue engineering.

Xiaoyue Xu, Erfeng Kou, Honglu Zhang, Kunyu Zhang, Huan Zhang

Abstract readReview

In one paragraph

Review in Fundamental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

The cutting-edge advancements in biomaterials under the guidance of intelligence and bionics.Regenerative biomaterials · 2026
Review
Biomaterials and materiobiology as the continuous powerhouse of biomedical innovation for our aging society.Fundamental research · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xiaoyue XuSchool of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China.

Erfeng KouSchool of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China.

Honglu ZhangSchool of Sensing Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.

Kunyu ZhangSchool of Biomedical Sciences and Engineering, Guangzhou International Campus, South China University of Technology, Guangzhou 511442, China.

Huan ZhangSchool of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bone defects are a common pathology in bone tissue diseases, and existing therapeutic interventions have significant limitations, highlighting the need for innovative strategies and advanced biomaterials. DNA, traditionally recognized as a prominent genetic material, also possesses exceptional properties as a biological material, making it an ideal nanoscale building block for creating various DNA-based biomaterials, such as DNA framework materials and DNA hydrogels. DNA-based biomaterials offer notable advantages, including structural versatility, biocompatibility, and, crucially, programmability, which position them as promising candidates for bone tissue engineering. This review explores recent advancements in the use of DNA-based biomaterials for bionic mineralization and drug delivery systems, as well as their future potential in this field.

Indexed as

Bone tissue engineeringDNA framework materialsDNA hydrogelsDNA nanotechnologyProgrammable biomaterials

Identifiers

PMID40777770

DOI10.1016/j.fmre.2024.12.015

PMCPMC12327870

What Socratic holds

Textmetadata

LicenceCC BY-NC-ND

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.