ArticleAmerican heart journal plus : cardiology research and practice2025
Hospitalization trends for thromboembolic events in atrial fibrillation: A 12-year national analysis.
Article in American heart journal plus : cardiology research and practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Direct oral anticoagulants and percutaneous left atrial appendage occlusion (LAAO) devices were approved for use in 2010 and 2015, respectively. It is unknown to what extent, if any, these new stroke preventive therapies have impacted hospitalizations for thromboembolic (TE) events. Objectives: To evaluate temporal trends in AF-related hospitalizations for acute ischemic stroke (AIS), transient ischemic attack (TIA), and systemic embolism (SEE) in the U.S. from 2010 to 2021. Methods: Using the National Inpatient Sample, we identified hospitalizations for TE events with comorbid AF. Data were grouped into two periods (2010-2015 and 2016-2021). Linear regression assessed trends in TE frequency. We also examined anticoagulation (AC) use and LAAO procedures among inpatients with AF. Results: A total of 1,692,373 AF-related TE hospitalizations were identified: 798,413 (2010-2015) and 893,960 (2016-2021). The frequency of hospitalizations for any AF-TE event, as a fraction of total hospitalizations in patients with AF, declined from 3.69 % to 3.35 % (P < 0.001). AF-related AIS hospitalizations rose from 2.71 % to 2.89 % in 2010-2015 (P < 0.001) but declined from 3.02 % to 2.89 % in 2016-2021 (P < 0.001). TIA (0.75 % to 0.35 %) and SEE (0.22 % to 0.10 %) hospitalizations also decreased (P < 0.001). AC use increased from 21.2 % in 2010 to 42.4 % in 2021 (P < 0.001), while LAAO procedures rose sharply from 5129 in 2016 to 46,080 in 2021 (P < 0.001). Conclusion: TE hospitalizations among inpatients with comorbid AF declined from 2010 to 2021, primarily driven by a decrease in TIAs and SEE. Acute ischemic stroke hospitalizations declined after 2016, coinciding with increased AC use and LAAO adoption.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.