Evidence map›Paper›PMID 40778473›Full record

ArticleMolecular medicine reports2025

Anti‑inflammatory and anti‑migratory properties of wild‑grape‑derived ε‑viniferin in human endometrial cells:  A potential therapy for endometriosis.

Yinzhi Lin, Yoshikazu Naiki, Shiori Kojima, Masatoshi Hakamata, Hitomi Fukatsu, Yoshiaki Hasegawa, Akihiko Wakatsuki, Naoki Koide, Kazuo Umezawa

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular medicine reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yinzhi LinDepartment of Molecular Target Medicine, Aichi Medical University, Nagakute, Aichi 480‑1195, Japan.
Yoshikazu NaikiDepartment of Microbiology, School of Dentistry, Aichi Gakuin University, Nagoya, Aichi 464‑8650, Japan.
Shiori KojimaDepartment of Molecular Target Medicine, Aichi Medical University, Nagakute, Aichi 480‑1195, Japan.
Masatoshi HakamataDepartment of Molecular Target Medicine, Aichi Medical University, Nagakute, Aichi 480‑1195, Japan.
Hitomi FukatsuFukuyu Medical Institute, Fukuyu Medical Corporation, Nisshin, Aichi 470‑0103, Japan.
Yoshiaki HasegawaDepartment of Microbiology, School of Dentistry, Aichi Gakuin University, Nagoya, Aichi 464‑8650, Japan.
Akihiko WakatsukiDepartment of Obstetrics and Gynecology, Aichi Medical University, Nagakute, Aichi 480‑1195, Japan.
Naoki KoideDepartment of Microbiology and Immunology, Aichi Medical University, Nagakute, Aichi 480‑1195, Japan.
Kazuo UmezawaDepartment of Molecular Target Medicine, Aichi Medical University, Nagakute, Aichi 480‑1195, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endometriosis is a chronic gynecological disorder characterized by the ectopic growth and proliferation of endometrial tissue outside the uterine cavity, leading to inflammation. Although low‑dose contraceptive pills are widely used for its treatment, these therapies are associated with side effects and are contraindicated in women trying to conceive. ε‑viniferin is a resveratrol dimer found in wild grapes (

Indexed as

Anti-Inflammatory AgentsBenzofuransCell MovementEndometriosisEndometriumStilbenesVitisAnimalsCell LineFemaleHumansInterleukin-6MiceNF-kappa BNitric OxidePlant ExtractsAnti-Inflammatory AgentsBenzofuransepsilon-viniferinInterleukin-6NF-kappa BNitric OxidePlant ExtractsReactive Oxygen SpeciesStilbenesendometriosisinflammationinvasionmigrationwild‑grape exactε‑viniferin

Identifiers

PMID40778473
PMCPMC12365741

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.