Evidence map›Paper›PMID 40778648›Full record

ArticlePediatric pulmonology2025

Associations Between Socioeconomic Status and Adherence to Medications in People With Cystic Fibrosis.

Gabriela R Oates, Kristin A Riekert, Christine Ford, Kimberly M Dickinson, Jennifer L Butcher, Diana Naranjo, Hanna Phan, Cori Daines, Hannah Grabowski, Michael S Schechter and 1 more

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In one paragraph

Article in Pediatric pulmonology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Gabriela R OatesPulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID https://orcid.org/0000-0003-4052-1524
Kristin A RiekertDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Christine FordDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland, USA.ORCID https://orcid.org/0009-0000-3855-770X
Kimberly M DickinsonDepartment of Pediatrics, Division of Pulmonary, Allergy/Immunology, Cystic Fibrosis and Sleep, Emory University, Atlanta, Georgia, USA.
Jennifer L ButcherDepartment of Pediatrics, Division of Pediatric Psychology, Mott Children's Hospital, Michigan Medicine, Ann Arbor, Michigan, USA.ORCID https://orcid.org/0000-0003-4991-5167
Diana NaranjoDepartment of Pediatrics, Division of Endocrinology, Stanford University, Stanford, California, USA.
Hanna PhanDepartment of Clinical Pharmacy, College of Pharmacy, University of Michigan, Ann Arbor, Michigan, USA.ORCID https://orcid.org/0000-0003-4968-1460
Cori DainesDepartment of Pediatrics, Division of Pulmonary and Sleep Medicine, University of Arizona, Tucson, Arizona, USA.
Hannah GrabowskiDivision of Pulmonary Medicine, Boston Children's Hospital, Boston, Massachusetts, USA.
Michael S SchechterChildren's Hospital of Richmond at Virginia Commonwealth University, Richmond, Virginia, USA.
Barriers Study Team

Funding

UAB CF Research and Translation Core CenterP30DK072482 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AMIT GAGGAR · 2007 to 2026
$23.0M
NIDDK NIH HHS P30 DK072482This work was supported by the Cystic Fibrosis Foundation (QUITTIN14Q10, SAWICK14PE1, RIEKER15PE0, and BARRIERS16PE0).
6 · The paper itself

Abstract

backgroundMedication adherence is essential in managing cystic fibrosis (CF). The role of socioeconomic factors for medication adherence in people with CF is poorly understood, and their differential impact across the life course is underexplored. This study investigates associations between measures of socioeconomic status (SES)-educational attainment, household income, and health insurance type-and adherence to CF medications across age groups.

methodsWe conducted a cross-sectional analysis of data collected during the validation of the Daily Care Check-In, a measure of adherence barriers in people with CF. Adherence was measured as a composite medication possession ratio (cMPR) averaged across five CF-specific medications, with data collected from pharmacy records. Sociodemographic and clinical data were collected through self-report and medical record review.

resultsA total of 405 participants completed the study, with an overall cMPR of 45.6%, lowest (38.5%) among young adults (aged 18-26 years) and highest (53.0%) among adolescents (aged 13-17 years). Lower household income and lack of college degree were associated with lower cMPR, more interference from adherence barriers, and decreased self-efficacy, as well as with increased depressive and anxiety symptoms. Similar associations, but less consistent, were observed for public health insurance. When stratified by age, associations between SES measures and adherence were most evident in adolescents, followed by adults, but absent in young adults, bringing into focus challenges with measuring SES in the 18-25 years age group.

conclusionLower SES is associated with worse medication adherence, more interference from adherence barriers, and lower self-efficacy. Associations vary by SES measure and age group, calling for a nuanced approach to adherence interventions in this population.

Indexed as

Cystic FibrosisMedication AdherenceSocial ClassAdolescentAdultChildCross-Sectional StudiesFemaleHumansIncomeInsurance, HealthMaleYoung Adultadherencecystic fibrosissocioeconomic status

Identifiers

PMID40778648
PMCPMC12333335

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.