Evidence map›Paper›PMID 40778827›Full record

ReviewJournal of cell science2025

Emerging roles of lipid transfer protein dimerization.

Shalom Borst Pauwels, Jacques Neefjes, Birol Cabukusta

Abstract readReview
In one paragraph

Review in Journal of cell science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Shalom Borst PauwelsCell and Chemical Biology, ONCODE Institute, Leiden University Medical Center, 2333ZA Leiden, Netherlands.ORCID 0000-0001-5596-2512
Jacques NeefjesCell and Chemical Biology, ONCODE Institute, Leiden University Medical Center, 2333ZA Leiden, Netherlands.ORCID 0000-0001-6763-2211
Birol CabukustaCell and Chemical Biology, ONCODE Institute, Leiden University Medical Center, 2333ZA Leiden, Netherlands.ORCID 0000-0002-1187-3048

Funding

Nederlandse Organisatie voor Wetenschappelijk Onderzoek NWO 00897590ONCODE Institute
6 · The paper itself

Abstract

The unique lipid composition of organelles defines their identity and is fundamental to their function. Lipid transfer proteins perform non-vesicular trafficking of lipids among cellular membranes to maintain their lipid compositions. Lipid transfer protein-mediated lipid trafficking is also essential for creating sub-organellar nano-domains that can recruit functional proteins or change the biophysical properties of membranes. The latest research focusing on the homo- and hetero-dimerization of lipid transfer proteins highlights the functional implications and the clinical significance of these events. Dimerization promotes lipid transfer protein localization at membrane contact sites and mediates the assembly of lipid transfer protein super-complexes to synchronize the transfer of different lipid types between organelles. Meanwhile, abnormal lipid flows caused by disarrangements in lipid transfer protein dimerization disturb organelle lipid landscapes, which has clinical consequences. This Review discusses the latest developments regarding the dimerization of lipid transfer proteins and their adaptor proteins that are critical for lipid trafficking between the organelles of the cell.

Indexed as

Carrier ProteinsProtein MultimerizationAnimalsHumansCarrier Proteinslipid transfer proteinDimerizationLipid transfer proteinsMembrane contact sitesNon-vesicular trafficking

Identifiers

PMID40778827
PMCPMC12377715

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.