Evidence map›Paper›PMID 40778925›Full record

ArticleJournal of studies on alcohol and drugs2026

More Than a Symptom Count: Measuring Functioning in Alcohol Use Disorder With the Life Stress Interview.

Dylan E Kirsch, Erica N Grodin, Danielle Keenan-Miller, Lara A Ray

Abstract read
In one paragraph

Article in Journal of studies on alcohol and drugs, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Dylan E KirschDepartment of Psychology, University of California, Los Angeles, Los Angeles, California.
Erica N GrodinDepartment of Psychology, University of California, Los Angeles, Los Angeles, California.
Danielle Keenan-MillerPrivate practice, Los Angeles, California.
Lara A RayDepartment of Psychology, University of California, Los Angeles, Los Angeles, California.

Funding

Clinical Neuroscience of Alcoholism: Integrating Neuroscience and Clinical TrialsK24AA025704 · NIAAA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LARA A. RAY · 2018 to 2026
$1.3M
Characterizing the Microbiome-Gut-Brain Axis in Individuals with Alcohol Use DisorderK01AA029712 · NIAAA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Erica N Grodin · 2022 to 2026
$819k
The effects of stress on decision-making in alcohol use disorder: A translational approachR21AA030643 · NIAAA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RAY, LARA A. · 2023 to 2024
$410k
A clinical neuroscience approach to understand stress coping in alcohol use disorderF32AA031425 · NIAAA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KIRSCH, DYLAN E · 2024 to 2024
$32k
NIAAA NIH HHS F32 AA031425NIAAA NIH HHS K01 AA029712NIAAA NIH HHS K24 AA025704NIAAA NIH HHS R21 AA030643
6 · The paper itself

Abstract

objectiveThe alcohol field has increasingly recognized that functioning plays a key role in the clinical course of alcohol use disorder (AUD). However, there remains a need for comprehensive instruments that capture functioning in this population. This study examined the utility of the UCLA Life Stress Interview Chronic Stress Assessment (LSI), a functional domains-based assessment widely used in mood disorder research, as a tool to measure functioning in key life domains in AUD. We (a) compared LSI scores between individuals with and without current AUD and (b) examined whether LSI scores are associated with recent alcohol use and AUD symptomology.

methodThis secondary case-control study included 38 adults with AUD and 35 age- and biological sex-matched controls. The LSI was used to assess functioning in interpersonal, occupational, personal health, and family health domains over the prior 6 months. The Timeline Followback was used to assess recent alcohol use, and the Structured Clinical Interview for DSM-5 was used to assess AUD symptomology.

resultsIndividuals with AUD exhibited significantly poorer interpersonal, occupational, and personal health functioning, compared with controls. Among individuals with AUD, worse interpersonal, occupational, and personal health functioning correlated with a higher number of AUD symptoms, and both interpersonal and occupational functioning also correlated with greater recent alcohol use.

conclusionsThis secondary study provides preliminary support for the LSI as a tool to assess functioning in AUD, offering an unbiased, addiction-independent evaluation of functioning across key domains. Future work should replicate results in larger samples, conduct a formal psychometric evaluation, and examine the effects of biological, demographic, and clinical factors.

Indexed as

AlcoholismInterview, PsychologicalStress, PsychologicalAdultCase-Control StudiesFemaleHumansMaleMiddle Aged

Identifiers

PMID40778925
PMCPMC13067937

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.