Evidence map›Paper›PMID 40778995›Full record

ArticleCellular and molecular life sciences : CMLS2025

SETD2 drives METTL14-mediated m

Shuai-Shuai Zhao, Chuan Yuan, Jin-Long Liu, Qi-Cai Wu, Xue-Liang Zhou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Shuai-Shuai Zhao *Department of Cardiovascular Surgery, the First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, Jiangxi, China.
Chuan Yuan *Department of Cardiovascular Surgery, the First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, Jiangxi, China.
Jin-Long LiuInstitute of Translational Medicine, Shanghai University, Shanghai, 200444, China.
Qi-Cai WuDepartment of Cardiovascular Surgery, the First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, Jiangxi, China. ndyfy00619@ncu.edu.cn.
Xue-Liang ZhouDepartment of Cardiovascular Surgery, the First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, Jiangxi, China. zhouxliang@ncu.edu.cn.

Funding

National Natural Science Foundation of China 81970199National Natural Science Foundation of China 82160082National Natural Science Foundation of China 82360060Natural Science Foundation of Jiangxi Province 20232ACB206003Natural Science Foundation of Jiangxi Province 20243BCE51022
6 · The paper itself

Abstract

backgroundPulmonary arterial hypertension (PAH) is characterized by pathological vascular remodeling driven by pulmonary artery smooth muscle cell (PASMC) proliferation. While METTL14-mediated N6-methyladenosine (m

methodsC57BL/6 mice were subjected to hypoxia, and pulmonary artery smooth muscle cells (PASMCs) were periodically stretched to establish PAH models in vivo and in vitro. The epigenetic regulation of METTL14 by SETD2-mediated H3K36me3 was investigated by chromatin immunoprecipitation (ChIP). Methylated RNA immunoprecipitation sequence (MeRIP-seq), RNA-seq, and dual-luciferase reporter gene data were used to determine whether METTL14 enhances the expression of Piezo1 in an m

resultsMETTL14 overexpression increased PASMC proliferation by 1.45-fold (vs. controls) and elevated global m

conclusionsThis study identifies a novel SETD2/H3K36me3/METTL14/m

Indexed as

AdenosineGTP-Binding ProteinsHistone-Lysine N-MethyltransferaseHypertension, PulmonaryIon ChannelsMethyltransferasesTransglutaminasesAnimalsCell ProliferationMaleMiceMice, Inbred C57BLMyocytes, Smooth MuscleProtein Glutamine gamma Glutamyltransferase 2Pulmonary ArteryVascular RemodelingAdenosineGTP-Binding ProteinsHistone-Lysine N-MethyltransferaseIon ChannelsMethyltransferasesMettl14 protein, mouseN-methyladenosinePiezo1 protein, mouseProtein Glutamine gamma Glutamyltransferase 2TransglutaminasesEpigenetic modificationMETTL14Piezo1Pulmonary arterial hypertensionSETD2

Identifiers

PMID40778995
PMCPMC12334401

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.