Evidence map›Paper›PMID 40778999›Full record

ReviewMolecular biology reports2025

Emerging landscape of lncRNA-miRNA interactions as architects of gene expression patterns.

Mohini Singh, Kanu Priya, Amka Nagar, Rohit Nalavade

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mohini SinghDepartment of Life Sciences, Sharda School of Basic Sciences and Research, Greater Noida, India.
Kanu PriyaDepartment of Life Sciences, Sharda School of Basic Sciences and Research, Greater Noida, India.
Amka NagarDepartment of Life Sciences, Sharda School of Basic Sciences and Research, Greater Noida, India.
Rohit NalavadeDepartment of Microbiology and Cell Biology, Indian Institute of Science, Bengaluru, Karnataka, 560012, India. rohitrn@iisc.ac.in.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Eukaryotic genome is highly complex and intricately organized, with nearly 98% of the human genome consisting of non-protein coding regions. Over the past few decades, extensive research has revealed a wealth of information within these non-coding elements, leading to the identification of various non-coding RNAs, including microRNAs (miRNAs), PIWI-interacting RNAs (piRNAs), long non-coding RNAs (lncRNAs), and other regulatory RNAs. Among these, lncRNAs have emerged as crucial regulators of diverse biological processes such as chromatin remodelling, transcriptional regulation, and epigenetic control. A particularly significant aspect of lncRNA function is their interaction with miRNAs, where they act as molecular scaffolds, decoys, guides, or sponges, modulating miRNA activity and influencing gene expression. These lncRNA-miRNA interactions play critical roles in regulating cellular pathways and have important implications in the onset and progression of diseases, including cancer, cardiovascular disorders, and neurodegenerative diseases. This review provides a comprehensive analysis of lncRNA biogenesis, their functional mechanisms, and their diverse roles in transcriptional and post-transcriptional regulation, with a special focus on the dynamic interplay between lncRNAs and miRNAs in gene regulation and disease progression.

Indexed as

Gene Expression RegulationMicroRNAsRNA, Long NoncodingAnimalsEpigenesis, GeneticHumansNeoplasmsPiwi-Interacting RNAMicroRNAsPiwi-Interacting RNARNA, Long NoncodingCancerInterplayLong noncoding RNAMALAT1MiRNAMiRNA precursor

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.