Evidence map›Paper›PMID 40779187›Full record

ReviewCardiovascular drugs and therapy2026

The Relationship and Mechanism of CD27 with Coronary Atherosclerotic Heart Disease.

Xue Fei Song, Fei Lin, Zhi Gang Chen, Guo An Zhao, Si Yu Sun, Jun Pu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cardiovascular drugs and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xue Fei SongDepartment of Xinxiang Medical University, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, 453001, Henan, China.
Fei LinDepartment of Cardiology, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, 453001, Henan, China. linfeixixi@aliyun.com.ORCID 0000-0003-0130-9985
Zhi Gang ChenDepartment of Cardiology, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, 453001, Henan, China.
Guo An ZhaoDepartment of Cardiology, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, 453001, Henan, China.
Si Yu SunDepartment of Life Sciences Research Center of Xinxiang Medical University First Affiliated Hospital, Xinxiang, 453001, Henan, China.
Jun PuDepartment of Shanghai JiaoTong University School of Medicine, Renji Hospital, Shanghai, 200001, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CD27, as a member of the immune checkpoints (IC), is physiologically expressed on various immune cells, with CD70 being its only known ligand. Together, they play a significant role in the co-stimulation and activation of T and B cells, regulating the body's immune response. Currently, the CD27/CD70 pathway shows great potential in the clinical treatment of tumors. Previous studies have found that immune checkpoint inhibitors (ICIs) provide significant benefits to cancer patients while also causing various adverse reactions, including cardiovascular diseases. The critical role of inflammation and adaptive immunity in coronary atherosclerotic heart disease (CAD) is widely recognized. Studies have found that the absence of CD27 or the blockade of the CD27/CD70 pathway exacerbates the occurrence of CAD. This review mainly summarizes the impact and mechanisms of CD27 and the CD27/CD70 pathway on CAD through immune regulatory pathways, providing important theoretical support for clinical treatment and prevention of adverse events in coronary heart disease, as well as new therapeutic strategies.

Indexed as

CD27 LigandCoronary Artery DiseaseTumor Necrosis Factor Receptor Superfamily, Member 7Adaptive ImmunityAnimalsHumansImmune Checkpoint InhibitorsSignal TransductionCD27 LigandCD70 protein, humanImmune Checkpoint InhibitorsTumor Necrosis Factor Receptor Superfamily, Member 7CD27Coronary heart diseaseImmune checkpointsInflammation

Identifiers

PMID40779187
PMCPMC13171740

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.