ArticleJournal of natural medicines2025
Anti-neuroinflammatory effects of epivernodalol, a sesquiterpene from Vernonia anthelmintica (L.) Willd., in lipopolysaccharide-stimulated murine microglial cells.
Article in Journal of natural medicines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
Funding
Abstract
Four terpenes-epivernodalol [Epl], cynaropicrin, vernonilide A, and vernodalin-were isolated from Vernonia anthelmintica (L.) Willd., and their effects on interleukin (IL)-6 secretion in lipopolysaccharide (LPS)-stimulated murine BV2 microglial cells were evaluated. To elucidate the underlying mechanisms of their immunomodulatory activity, we quantified the mRNA levels of key cytokines (IL-1β, TNF-α, IL-6, IL-10, and TGF-β) and the expression of CD206 using qRT-PCR. Additionally, surface markers of BV2 cells were analyzed via flow cytometry. Furthermore, we assessed the phosphorylation of NF-κB and its inhibitory protein, IκB, in BV2 microglial cells by western blotting. Our findings demonstrated that Epl exerts anti-neuroinflammatory effects by suppressing NF-κB pathway activation and pro-inflammatory cytokine secretion while enhancing anti-inflammatory cytokines production and promoting M2 polarizations. This study not only reveals a previously unrecognized role of Epl but also provides insights into the identification of novel therapeutic targets for neuroinflammatory diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.