Evidence map›Paper›PMID 40780310›Full record

ReviewJournal of advanced research2026

Innovative applications of multidimensional engineered hydrogels in wound healing.

Min Hu, Qiaoyan Zhang, Luping Qin

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of advanced research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Min HuZhejiang Chinese Medical University, Hangzhou, China. Electronic address: 20241159@zcmu.edu.cn.
Qiaoyan ZhangZhejiang Chinese Medical University, Hangzhou, China. Electronic address: zqy1965@163.com.
Luping QinZhejiang Chinese Medical University, Hangzhou, China. Electronic address: lpqin@zcmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe skin, as the largest organ of the human body, functions as a critical protective barrier against external threats such as pathogens, mechanical damage, and temperature extremes while regulating physiological homeostasis. However, acute and chronic wounds-ranging from surgical injuries to diabetic ulcers-pose significant global health and economic challenges due to their complex, often dysregulated healing processes involving intertwined cellular, molecular, and microenvironmental factors. Conventional dressings (gauze, films) face limitations in moisture regulation, mechanical compatibility, and bioactive modulation. Engineered hydrogels, with high water content, ECM-mimetic structures, and tunable properties, offer transformative solutions. While existing reviews focus on materials (natural/synthetic polymers) and fabrication (crosslinking, 3D printing), systematic analysis of innovative therapeutic applications remains underexplored. AIM OF REVIEW: This review systematically summarizes innovative hydrogel strategies spanning three key dimensions: functional (growth factor controlled release, cell/exosome delivery, coordinated regulation of inflammation and oxidative stress, angiogenesis promotion, and antibacterial defense), structural (multilayered biomimetic architectures and dynamic network designs), and technological (bioprinting and microfluidic techniques). It further explores the potential of cross-dimensional (function-structure-technology) synergy in advanced wound management. Considering current research challenges, future directions for constructing multidimensional-integrated engineered smart hydrogels are proposed, providing insights for developing intelligent wound dressings in the era of personalized precision medicine. KEY SCIENTIFIC CONCEPTS OF REVIEW: Multidimensional Hydrogel Design: Integration of functional (controlled delivery, immunomodulation, angiogenesis, antibacterial), structural (biomimetic layering, dynamic networks), and technological (bioprinting, microfluidics) strategies; Cross-Dimensional Synergy: The synergistic effect of function-structure-technology intergration in advanced wound management; Intelligent Wound Dressings: Application of smart hydrogel platforms towards personalized medicine in wound healing.

Indexed as

HydrogelsWound HealingAnimalsBandagesBioprintingHumansPrinting, Three-DimensionalTissue EngineeringHydrogelsHydrogelsMultidimensional engineered hydrogelsPersonalized treatmentWound healing

Identifiers

PMID40780310
PMCPMC13131448

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.