Evidence map›Paper›PMID 40781239›Full record

ArticleNature communications2025

Dynamically urethra-adapted and obligations-oriented trilayer hydrogels integrate scarless urethral repair.

Ming Yang, Maocheng Zuo, Ranxing Yang, Kaile Zhang, Ruonan Jia, Binxu Yin, Ying Wang, Meng Liu, Wenzhuo Fang, Huaijuan Guo and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ming Yang *Department of Urology, affiliated Sixth People's Hospital, Shanghai Jiaotong University, Shanghai, PR China.
Maocheng Zuo *Department of Orthopedics and Central Laboratory, Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Ranxing Yang *Department of Urology, affiliated Sixth People's Hospital, Shanghai Jiaotong University, Shanghai, PR China.
Kaile Zhang *Department of Urology, affiliated Sixth People's Hospital, Shanghai Jiaotong University, Shanghai, PR China.
Ruonan JiaDepartment of Orthopedics and Central Laboratory, Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.ORCID http://orcid.org/0000-0003-2653-3342
Binxu YinDepartment of Orthopedics and Central Laboratory, Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Ying WangDepartment of Urology, affiliated Sixth People's Hospital, Shanghai Jiaotong University, Shanghai, PR China.
Meng LiuDepartment of Urology, affiliated Sixth People's Hospital, Shanghai Jiaotong University, Shanghai, PR China.
Wenzhuo FangDepartment of Urology, affiliated Sixth People's Hospital, Shanghai Jiaotong University, Shanghai, PR China.
Huaijuan GuoDepartment of Orthopedics and Central Laboratory, Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Yangwang JinDepartment of Urology, affiliated Sixth People's Hospital, Shanghai Jiaotong University, Shanghai, PR China.ORCID http://orcid.org/0009-0000-4315-1552
Qiang FuDepartment of Urology, affiliated Sixth People's Hospital, Shanghai Jiaotong University, Shanghai, PR China. jamesqfu@126.com.
Kun ZhangDepartment of Orthopedics and Central Laboratory, Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China. zhang1986kun@126.com.ORCID http://orcid.org/0000-0002-6971-1164

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82022033National Natural Science Foundation of China (National Science Foundation of China) 82170694Sichuan Provincial Department of Science and Technology | Sichuan Province Science and Technology Support Program 2024NSFJQ0048
6 · The paper itself

Abstract

In urethral damage/stricture prevention, open and harsh urethral microenvironments and isotropic compression and swelling properties of exogenous implants render urethral repair intractable. Here a dynamically urethra-adapted and obligations-oriented trilayer hydrogel was engineered to integrate scarless urethral repair. Therein, the diethylacrylamide-hydroxyethylacrylamide (HEAm) (D-H) hydrogel layer featuring high anti-fouling performance prevent adhesions of bacterial and blood cells, and its poor swelling avoids urethra occlusion. The upper swellable and verteporfin (VP)-loaded N,N'-methylenebisacrylamide-poly (N-isopropylacrylamide) (BP) layer encourages urethra regeneration through expediting cell migration and proliferation. The rigid and water-resistant Zein middle layer opposes urine voiding-arised BP shedding, urethral diastole/contraction, inward BP swelling-arised urethra occlusion and urine permeation. Importantly, systematic proteomic and genomic analysis reveals that such hydrogel scaffolds expedite epithelial & vascular regenerations, attenuate tight cell junction, oppose inflammation microenvironment and regulate extracellular matrix secretion and metabolism to realize integrated urethral repair. The microenvironment-adaptable design concepts provide reliable rationales to engineer urethral regeneration scaffolds.

Indexed as

HydrogelsUrethraAcrylic ResinsAnimalsHumansMaleMiceRegenerationTissue EngineeringTissue ScaffoldsAcrylic ResinsHydrogels

Identifiers

PMID40781239
PMCPMC12334618

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.