SynthesisBMC infectious diseases2025
The magnitude of flaviviruses infection in Ethiopia: a systematic review and meta-analysis.
Synthesis in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFlaviviruses are a well-known mosquito borne viruses and their nucleic acid is single-stranded RNA which is enclosed with the capsid and envelop. Flavivirus infections can cause a wide variety of clinical manifestations and complications in humans. Outbreaks have been recorded due to DENV and YFV infections in Ethiopia in different time. The aim of the present systematic review and meta-analysis (SRMA) is to determine the overall magnitude of flaviviruses infection in Ethiopia.
methodsInitially reported under the registration number CRD42023492735, this SRMA was subsequently carried out in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) standards. The search for appropriate resources took place from December 10, 2023, to January 10, 2024, using a number of electronic databases, including PubMed, Google Scholar, Wiley Online Library, African Journal Online, Science Direct, ResearchGate, and Web of Sciences. Additionally, the quality of the included studies was evaluated using the Joanna Briggs Institute (JBI) assessment tool. The statistical analysis was conducted using Stata version 14.0. In addition to funnel plot and Egger's test, which were used to detect publication bias, Cochran's Q test and I2 statistics were employed to measure heterogeneity. The pooled prevalence was estimated via a random effect model.
resultsThe overall pooled prevalence of flaviviruses infection in Ethiopia was found to be 12.67% (95% CI: 11.00-14.35). The highest pooled prevalence of 23.49% (17.53-29.45) was observed in DENV followed by ZIKV, 13.63% (12.73-40.00). The sero-prevalence markers of IgG and IgM for flaviviruses were detected among 12.18% and 7.41% patients, respectively. The highest pooled prevalence of flavivirus was demonstrated in studies conducted in health care facilities (17.32%). The sensitivity test exhibits that no single study had an impact on the overall pooled effect magnitude. The symmetry of the funnel plot and the Egger's test statistics indicated publication bias.
conclusionsThe pooled prevalence of flaviviruses infection in Ethiopia was high and DENV was the commonest flavivirus observed in the country. Nationwide surveillance of flaviviruses infection among human population should be conducted. Prompt prevention and control strategies should be implemented particularly in outbreak prone areas.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.