Evidence map›Paper›PMID 40781663›Full record

Observational studyBMC pregnancy and childbirth2025

Baseline values for Quantra

Suthawan Anakmeteeprugsa, Antonio Gonzalez-Fiol, Angelique Garay, Hung-Mo Lin, Zili He, Aymen Alian

Abstract readObservational StudyComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC pregnancy and childbirth, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. ClotProBMC pregnancy and childbirth · 2026
    Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Suthawan AnakmeteeprugsaDepartment of Anesthesiology, Yale University School of Medicine, PO Box 208051, 333 Cedar Street, New Haven, CT, 06520, USA.
Antonio Gonzalez-FiolDepartment of Anesthesiology, Yale University School of Medicine, PO Box 208051, 333 Cedar Street, New Haven, CT, 06520, USA.
Angelique GarayDepartment of Anesthesiology, Yale University School of Medicine, PO Box 208051, 333 Cedar Street, New Haven, CT, 06520, USA.
Hung-Mo LinDepartment of Anesthesiology, Yale University School of Medicine, PO Box 208051, 333 Cedar Street, New Haven, CT, 06520, USA.
Zili HeYale Center for Analytical Sciences, Yale University School of Public Health, New Haven, CT, USA.
Aymen AlianDepartment of Anesthesiology, Yale University School of Medicine, PO Box 208051, 333 Cedar Street, New Haven, CT, 06520, USA. aymen.alian@yale.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHypofibrinogenemia is associated with progression from moderate to severe postpartum hemorrhage (PPH). Early recognition and replacement of fibrinogen are emphasized during the management of PPH. The Quantra

methodsHealthy pregnant women in labor or scheduled for elective cesarean delivery (CD) were enrolled in our prospective observational study. Blood samples for Quantra and standard laboratory coagulation tests were taken simultaneously. Quantra values, standard laboratory coagulation test, time of blood collected, and time to the result were recorded. We compared the baseline values between CD and labor group using a t-test, and the correlation between Quantra and standard laboratory coagulation test was calculated using partial Pearson correlation.

results170 healthy pregnant women were included; 126 cases were in the CD group, and 44 patients were in the labor group. We found a strong correlation between Quantra Fibrinogen contribution to Clot Stiffness (FCS) and fibrinogen level (r = 0.67). The median [interquartile range] time of fibrinogen results by Quantra was 36 [28, 48] minutes faster than the standard laboratory coagulation tests. Baseline ranges for Quantra values, which were not significantly different between the two groups, demonstrated hyperfibrinogenemia during pregnancy.

conclusionQuantra is a novel POCVT device that rapidly provides coagulation status in pregnant women. The strong correlation between FCS and fibrinogen level can be helpful for early recognition of hypofibrinogenemia for the management of PPH.

Indexed as

Point-of-Care TestingThrombelastographyAdultBlood CoagulationBlood Coagulation TestsCesarean SectionFemaleFibrinogenHumansLabor, ObstetricPostpartum HemorrhagePregnancyProspective StudiesReference ValuesFibrinogenBlood coagulation testHypofibrinogenemiaPoint-of-care viscoelastic testingPostpartum hemorrhage

Identifiers

PMID40781663
PMCPMC12333236

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.