Trial reportHuman brain mapping2025
Effects of Oral Contraceptive Pills on Brain Networks: A Conceptual Replication and Extension.
Trial report in Human brain mapping, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Effects of Oral Contraceptive Pills on Brain Networks: A Conceptual Replication and Extension.Human brain mapping · 2025Trial
- Reproductive lifespan and hormonal therapy in relation to later-life neurovascular health: A population-based study of women in the Gothenburg H70-1944 Birth Cohort.medRxiv : the preprint server for health sciences · 2026Article
Corrections and comments
- Update of
Authors and funding
6 authors.
Funding
Abstract
Neuroimaging studies have reported that oral contraceptive pills (OCPs) alter brain connectivity, but findings have varied widely and are often derived from observational designs. Here, we used a randomized, double-blind, placebo-controlled crossover design to test for conceptual replication of three prior studies and to explore broader network-level effects of OCPs. Replication analyses largely did not confirm previously reported seed-based connectivity changes in edges containing amygdala, putamen, or dorsal anterior cingulate nodes (ps > 0.05). In the absence of a clear replication, we pursued exploratory analyses using functional connectome fingerprinting, a multivariate, data-driven method that allows parsimonious interrogation of connectivity changes simultaneously across the whole by detecting whole-brain connectivity patterns that distinguish individuals from one another. This approach revealed network-level changes during OCP use, especially within subcortical, executive, and somatomotor circuits. OCPs also increased between-subject similarity in functional connectomes (I
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.