ArticleClinical pharmacokinetics2025
Drug-Drug Interactions Between Direct Oral Anticoagulants and Other Medications in Patients with Pulmonary Embolism: Results from the Lungenembolie Augsburg (LEA).
Article in Clinical pharmacokinetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
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Abstract
BACKGROUND AND
aimDirect oral anticoagulants (DOACs) are now a well-established class of medication for blood clot prevention and treatment. So far, literature evaluating real-world data on the drug-drug interactions (DDIs) between DOACs and other medications in patients with pulmonary embolism (PE) is limited. This study aims to investigate these interactions in patients with PE to address this and improve patient care. MATERIALS AND
methodsIn a retrospective study, patients' medications were recorded upon hospital discharge and reviewed again 3 months later. A clinical decision support system (AiDKlinik
resultsThe 477 included PE patients had a median intake of five drugs. Drug-anticoagulation interactions depended strongly on the number of medications taken (P value < 0.001). However, the association was non-linear, resulting in a saturation effect for a higher number of drugs. The odds ratio for having at least one drug-anticoagulation interaction was 0.40 (95% confidence interval 0.17-0.96; P value = 0.040) in patients with hypertension.
conclusionsThe potential for DDIs with DOACs represents a significant concern. By being aware of the most common interactions, risk factors and avoidance strategies, the safety and efficacy of therapy can be optimized.
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40782145What Socratic holds
Registered trials
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