ArticleScientific reports2025
Multi-omics analysis of bariatric surgery's impact on type 2 diabetes and prediabetes.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Sleeve gastrectomy protects lean mice from future obesity.bioRxiv : the preprint server for biology · 2026Article
- Pharmacogenomics in the United Arab Emirates: advances in population genomics and challenges in clinical implementation.Frontiers in pharmacology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors.
Funding
Abstract
Bariatric surgery is a promising intervention for managing obesity-related metabolic disorders; however, its effects on cardiovascular disease (CVD) in individuals with type 2 diabetes (T2D) remain poorly understood. To address this gap, we utilized a multi-omics approach to investigate how bariatric surgery influences Emirati individuals with T2D and prediabetes, focusing on the early detection of CVD markers. We longitudinally profiled 19 patients over a 9-month period, collecting omics data, including whole-genome sequencing (WGS), protein immunoassays, untargeted metabolomics, and 16S rRNA sequencing to determine gut microbiome composition. Through this study, we showed that bariatric surgery reduced CVD risk and inflammatory biomarkers while inducing changes in the gut microbiome and metabolomic profiles. We identified four inflammatory biomarkers (FGF-basic, TNFSF13, IL-8, and IL-1Ra) that were significantly altered following surgery (p < 0.05). Additionally, we identified 98 metabolites that showed significant changes after surgery that are involved in folate biosynthesis, glycerophospholipid, and retinol metabolism. Eighteen microbial genera were found to differentiate between the pre- and post-surgery states. Our analysis revealed four microbial genera (Enterobacter, Enterococcus, Gemella, and Erysipelotrichaceae UCG-003) associated with two T2D SNPs (rs11830243 and rs6978118) and three CVD SNPs (rs9490306, 62207434, and rs34606058). These genera formed the network's central hub, connecting host genetic variants, metabolic pathways, and clinical data, highlighting their role in host-microbiome interactions. The study quantifies the impact of phenotypic factors on CVD progression among UAE nationals, contributing to a deeper understanding of cardiometabolic health within this population.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.