ArticleBMC cardiovascular disorders2025
Red cell distribution width-to-albumin ratio and hypertension risk: age-specific threshold effects identified in the 2017-2020 NHANES U.S. Adult population.
Article in BMC cardiovascular disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Association of the red blood cell distribution width-to-albumin ratio with incident depression and depressive symptom trajectories in older adults.European archives of psychiatry and clinical neuroscience · 2026Article
- The association between red blood cell distribution width-to-albumin ratio andFrontiers in nutrition · 2026Article
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3 authors.
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Abstract
backgroundAs a major modifiable risk factor for cardiovascular diseases worldwide, hypertension novel biomarkers that integrate inflammatory and metabolic pathways may improve risk stratification. The association between the red cell distribution width-to-albumin ratio (RAR), a newly identified inflammatory biomarker, and hypertension has not been systematically evaluated in population-based studies.
methodsA cross-sectional study included 7,878 adults. Weighted multivariable logistic regression and threshold effect models were employed to analyze nonlinear associations, with subgroup analyses exploring heterogeneity.
resultsRAR showed a linear positive association with hypertension (adjusted OR = 1.26 per unit, 95%CI:1.09-1.44, P < 0.05), a threshold effect was observed. Piecewise regression revealed a significant association when RAR ≥ 3.4, with a higher hypertension prevalence (adjusted OR = 1.34, 95%CI:1.17-1.54), while no association existed below 3.4 (P = 0.408). For those aged 40-60 years, the inflection point was RAR = 3.92 (95%CI:3.76-4.51), with stronger associations observed below this threshold (OR = 1.80, 95%CI:1.33-2.43). Subgroup analyses revealed significant heterogeneity: diabetics exhibited stronger associations than non-diabetics (interaction P = 0.02), and enhanced associations were also observed in females and individuals aged > 40 years.
conclusionThis study confirmed a linear positive correlation between red blood cell distribution width and albumin ratio (RAR) and the prevalence of hypertension, RAR ≥ 3.4 was associated with higher hypertension prevalence and may help identify high-risk subgroups, particularly among diabetics, but its predictive value warrants validation through prospective cohort studies.
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