Evidence map›Paper›PMID 40784341›Full record

ArticleJournal of vascular research2025

Exposure to Artificial Light at Night Alters Ultradian Rhythms in Endothelial Function.

James C Walton, O Hecmarie Meléndez-Fernández, A Courtney DeVries, Paul D Chantler, Randy J Nelson

Abstract read
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In one paragraph

Article in Journal of vascular research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

James C WaltonDepartment of Neuroscience, West Virginia University, Morgantown, West Virginia, USA.
O Hecmarie Meléndez-FernándezDepartment of Neuroscience, West Virginia University, Morgantown, West Virginia, USA.
A Courtney DeVriesDepartment of Neuroscience, West Virginia University, Morgantown, West Virginia, USA.
Paul D ChantlerDepartment of Neuroscience, West Virginia University, Morgantown, West Virginia, USA.
Randy J NelsonDepartment of Neuroscience, West Virginia University, Morgantown, West Virginia, USA.

Funding

Effects of Light at Night and Disrupted Circadian Rhythms on PainR21AT011238 · NCCIH · WEST VIRGINIA UNIVERSITY · PI Randy J. Nelson · 2022 to 2022
$190k
NCCIH NIH HHS R21 AT011238NIGMS NIH HHS P20 GM109098NINDS NIH HHS R01 NS092388
6 · The paper itself

Abstract

introductionEndogenous biological timing mechanisms are fundamental aspects of living cells, tissues, and organisms. Virtually every aspect of physiology and behavior is mediated by self-sustaining circadian clocks, which depend on light to synchronize with the external daily environment. However, exposure to artificial light at night (ALAN) can impair temporal adaptations and affect health and disease.

methodsDuring a study of the effects of long-term ALAN exposure on cardiovascular function, we serendipitously detected ultradian rhythms in muscarinic receptor dependent relaxation of isolated aortic tissue. RESULTS AND

conclusionMice exposed to dark nights displayed an ultradian pattern of maximum endothelial-dependent relaxation that was antiphase between the sexes. Rhythmic patterns of relaxation were abolished by ALAN exposure in both sexes suggesting that ALAN exposure can affect ultradian rhythms in physiology and behavior.

Indexed as

Circadian RhythmEndothelium, VascularLightPhotoperiodVasodilationAnimalsAortaFemaleMaleMiceMice, Inbred C57BLSex FactorsTime FactorsCircadianEndothelia tissueLight at nightRhythmsUltradian

Identifiers

PMID40784341
PMCPMC12439349

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.