ArticleNeuroimmunomodulation2025
Melanocortin Receptor-Mediated Anti-Inflammatory Effect of Acthar® Gel in Human Myeloid Cells.
Article in Neuroimmunomodulation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
<p>Introduction: Acthar® Gel, a complex mixture of porcine adrenocorticotropic hormone analogs that activates all 5 melanocortin receptor (MCR) subtypes, is an approved noncorticosteroid treatment for multiple sclerosis (MS) exacerbations.
methodsMCR expression and anti-inflammatory effects of Acthar Gel in human monocyte-derived macrophages (MDMs) and human brain-derived microglia were investigated following lipopolysaccharide stimulation in vitro.
resultsMC1R was expressed at substantially higher levels than the other MCR subtypes in human MDMs and was the only MCR gene detected in human adult microglia. As shown by microarray gene expression analysis, polarization of MDMs to a pro-inflammatory phenotype increased the expression and secretion of interleukin-6, tumor necrosis factor α, and CXC motif chemokine ligand 10, which were inhibited in a dose-dependent manner with Acthar Gel treatment.
conclusionsThese results are consistent with previous insights that Acthar Gel has an immunomodulatory mechanism distinct from glucocorticoids alone and suggest that Acthar Gel can improve clinical outcomes in MS and other inflammation-mediated central nervous system disorders by inhibiting multiple pro-inflammatory cytokine signaling pathways. </p>.
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