Evidence map›Paper›PMID 40784914›Full record

ArticleScientific reports2025

Harnessing electroacupuncture: a promising strategy against sleep deprivation-exacerbated post-cardiac arrest brain injury.

Wenchao Fu, Cong Hu, Can Ma, Shihua Lv, Xianzhang Zeng, Tingting Li, Jiahui Chen, Xiao Han, Xin Tan, Xuefei Li and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Wenchao Fu *Heilongjiang Key Laboratory of Anesthesiology and Intensive Care, Harbin Medical University, Harbin, 150001, Heilongjiang Province, China.
Cong Hu *Heilongjiang Key Laboratory of Anesthesiology and Intensive Care, Harbin Medical University, Harbin, 150001, Heilongjiang Province, China.
Can MaHeilongjiang Key Laboratory of Anesthesiology and Intensive Care, Harbin Medical University, Harbin, 150001, Heilongjiang Province, China.
Shihua LvHeilongjiang Key Laboratory of Anesthesiology and Intensive Care, Harbin Medical University, Harbin, 150001, Heilongjiang Province, China.
Xianzhang ZengHeilongjiang Key Laboratory of Anesthesiology and Intensive Care, Harbin Medical University, Harbin, 150001, Heilongjiang Province, China.
Tingting LiThe first affiliated hospital, Sun Yat-sen University, Guangzhou, 510000, Guangdong Province, China.
Jiahui ChenHeilongjiang Key Laboratory of Anesthesiology and Intensive Care, Harbin Medical University, Harbin, 150001, Heilongjiang Province, China.
Xiao HanHeilongjiang Key Laboratory of Anesthesiology and Intensive Care, Harbin Medical University, Harbin, 150001, Heilongjiang Province, China.
Xin TanHeilongjiang Key Laboratory of Anesthesiology and Intensive Care, Harbin Medical University, Harbin, 150001, Heilongjiang Province, China.
Xuefei LiHeilongjiang Key Laboratory of Anesthesiology and Intensive Care, Harbin Medical University, Harbin, 150001, Heilongjiang Province, China.
Wenzhi LiHeilongjiang Key Laboratory of Anesthesiology and Intensive Care, Harbin Medical University, Harbin, 150001, Heilongjiang Province, China. wenzhili9@126.com.ORCID http://orcid.org/0000-0003-4196-524X

Funding

the National Natural Science Foundation of China No.81871025
6 · The paper itself

Abstract

Cardiac arrest (CA)-induced post-cardiac arrest brain injury (PCABI) represents a critical contributor to global mortality and neurological disability. While sleep deprivation (SD) is recognized to aggravate neurological outcomes, its role in PCABI pathogenesis remains underexplored. This study investigated the mechanisms by which SD exacerbates PCABI and evaluated the neuroprotective efficacy of electroacupuncture (EA). A CA model was established in SD rats, followed by RNA sequencing and molecular analyses to assess brain injury biomarkers, synaptic plasticity, and calcium signaling pathways. SD disrupted circadian rhythms, amplified neuronal apoptosis, and suppressed glutamate transporter Excitatory Amino Acid Transporter 2 (EAAT2) expression post-CA, correlating with worsened cognitive deficits. EA treatment significantly attenuated these effects, restoring EAAT2 levels, mitigating calcium overload, and enhancing synaptic integrity. Mechanistically, EA modulated the EAAT2/calcium signaling axis and rebalanced autonomic nervous activity, thereby reducing oxidative stress and neuronal excitotoxicity. These findings identify EAAT2 downregulation as a key mediator of SD-aggravated PCABI and establish EA as a dual-target intervention that rectifies glutamatergic dysregulation and autonomic dysfunction. The study provides translational insights into EA's therapeutic potential for PCABI, particularly in populations with comorbid sleep disturbances.

Indexed as

Brain InjuriesElectroacupunctureHeart ArrestSleep DeprivationAnimalsDisease Models, AnimalExcitatory Amino Acid Transporter 2MaleNeuronal PlasticityOxidative StressRatsRats, Sprague-DawleyExcitatory Amino Acid Transporter 2Slc1a2 protein, ratBrain injuryCardiac arrestEAAT2ElectroacupunctureSleep deprivation

Identifiers

PMID40784914
PMCPMC12336346

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.