Evidence map›Paper›PMID 40785227›Full record

ArticleACS chemical neuroscience2025

Divalent and Trivalent Metallic Ions Differentially Affect Alpha-Synuclein Aggregation.

Noah J Graves, Ali K Jaafar, Yann Gambin, Emma Sierecki

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS chemical neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Noah J GravesEMBL Australia Node for Single Molecule Sciences and School of Biomedical Sciences, Faculty of Medicine, The University of New South Wales, Sydney, New South Wales 2052, Australia.ORCID 0009-0004-5507-7838
Ali K JaafarEMBL Australia Node for Single Molecule Sciences and School of Biomedical Sciences, Faculty of Medicine, The University of New South Wales, Sydney, New South Wales 2052, Australia.
Yann GambinEMBL Australia Node for Single Molecule Sciences and School of Biomedical Sciences, Faculty of Medicine, The University of New South Wales, Sydney, New South Wales 2052, Australia.
Emma SiereckiEMBL Australia Node for Single Molecule Sciences and School of Biomedical Sciences, Faculty of Medicine, The University of New South Wales, Sydney, New South Wales 2052, Australia.ORCID 0000-0001-9970-868X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alpha-synuclein (αSyn) is the constituent protein associated with neurodegenerative synucleinopathies such as Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. Recent studies have highlighted the potential role of altered metal ion homeostasis in influencing the aggregation and pathological behavior of αSyn, thereby affecting disease progression. We examined αSyn aggregation propensity in the presence of calcium (Ca

Indexed as

alpha-SynucleinMetalsProtein AggregatesProtein Aggregation, PathologicalAluminumCalciumCations, DivalentCopperHumansIronMagnesiumZincalpha-SynucleinAluminumCalciumCations, DivalentCopperIronMagnesiumMetalsProtein AggregatesZincalpha-synucleinamyloidkineticsmetal ionsParkinson’s diseasestrains

Identifiers

PMID40785227
PMCPMC12447500

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.