ArticlePhotodermatology, photoimmunology & photomedicine2025
Photosensitivity Episodes Related to Skin Color in People Treated With Dual-Wavelength Low Power Laser Therapy: A Retrospective Cohort Study.
Article in Photodermatology, photoimmunology & photomedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Effects of Vascular Photobiomodulation on Glycemic Control in Patients With Type II Diabetes Mellitus: A Prospective Single-Arm Clinical Study.Lasers in surgery and medicine · 2026Trial
- Photobiomodulation for salivary gland dysfunction: aligning clinical expectations with etiology-dependent treatment responsiveness.Lasers in medical science · 2026Review
- Pigmentation-dependent skin injury thresholds with nanosecond single-pulse laser exposure.Journal of biomedical optics · 2026Article
- Photosensitivity Episodes Related to Skin Color in People Treated With Dual-Wavelength Low Power Laser Therapy: A Retrospective Cohort Study.Photodermatology, photoimmunology & photomedicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
background/purposeThe therapeutic use of low-level lasers aims to promote tissue photobiomodulation without raising the local temperature. However, in darker-skin patients, melanin can increase temperature and cause adverse effects such as photosensitivity, especially in protocols with higher irradiances, such as those used in dual irradiations. Therefore, through a retrospective cohort, this project assesses the relationship between self-reported skin color and the frequency of photosensitivity in patients treated with simultaneous dual irradiation protocols at the School of Dentistry of the University of São Paulo.
methodsData from patients treated with lasers between 2013 and 2023 were retrieved. Patients were divided into two groups based on skin color and assessed for photosensitivity after simultaneous irradiation with red and infrared wavelengths. Statistical analyses investigated the relationship between photosensitivity, skin color, patient characteristics, and delivered energy.
resultsSelf-reported skin color was associated with photosensitivity, with dark-skinned patients having a three times higher risk of heating or thermal injury. The risk of clinically visible thermal injuries was nearly 12 times higher for this group compared to those with lighter skin. There was no correlation between the energy used and the degree of photosensitivity, nor was there a significant difference in energy between patients with and without photosensitivity.
conclusionSelf-reported skin color was associated with photosensitivity occurrence during simultaneous laser wavelengths irradiation. Further studies are needed to investigate the mechanisms underlying the relation between melanin and irradiance. Finally, individualized photobiomodulation protocols are needed to ensure patient safety and optimize the therapy's expected effects.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.