ReviewFrontiers in pharmacology2025
From traditional remedy to modern therapy: a comprehensive review of palmatine's multi-target mechanisms and ethnopharmacological potential.
Review in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Palmatine-Intercalated Montmorillonite Improves Intestinal Health and Attenuates Systemic Inflammation in ETEC-Challenged Piglets.Animals : an open access journal from MDPI · 2026Article
- Integrated Metabolomics and Transcriptomics Analysis Reveals the Biosynthetic Mechanism of Isoquinoline Alkaloids in Different Tissues ofCurrent issues in molecular biology · 2026Article
- Advances in natural compounds modulating autophagy for the therapeutic intervention of heart failure.Molecular and cellular biochemistry · 2026Review
- Two Drug-Drug Co-Amorphous Systems of Curcumin and Berberine Hydrochloride/Palmatine Hydrochloride with Improved Physicochemical Properties and Multifunctional Activities.Pharmaceutics · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: As a core active metabolite of traditional Chinese medicines including Methods: In accordance with the PRISMA guidelines, a comprehensive literature search was conducted using PubMed, Web of Science, and Embase databases. The search terms included "Palmatine," "Disease," " Results: Studies demonstrate palmatine's multi-target mechanisms through regulation of NF-κB/NLRP3, Nrf2/HO-1, and AMPK/mTOR signaling pathways, mediating anti-inflammatory, antioxidant, and metabolic-modulating effects. Its exceptional blood-brain barrier permeability confers distinct advantages for central nervous system disorders, while its metabolites such as 8-oxypalmatine display superior bioactivity. In anticancer applications, palmatine functions through multiple mechanisms encompassing direct tumor cell cytotoxicity, metastasis suppression, and angiogenesis inhibition, while maintaining dose-dependent safety characteristics. Conclusion: Palmatine serves as a bridge connecting traditional medicine and modern therapy, offering novel strategies for complex diseases through its polypharmacological actions. Although limited by low bioavailability, clinical potential can be enhanced via combination therapies, structural modifications such as C13 alkylation, and nano-delivery systems. Future research should prioritize exploration of synergistic effects, targeted delivery technologies, and large-scale clinical validation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.