Evidence map›Paper›PMID 40786249›Full record

ReviewDrug design, development and therapy2025

Therapeutic Implications of Traditional Chinese Medicine in Clinically Relevant Diseases: Perspectives From microRNA-Modulated Apoptotic Signaling.

Qinzheng Xu, Di Wu, Jiachen Tan, Faheem Ahmed Khan, Nuruliarizki Shinta Pandupuspitasari, Chunjie Huang

Abstract readReview
In one paragraph

Review in Drug design, development and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Qinzheng Xu *School of Medicine, Nantong University, Nantong, 226001, People's Republic of China.
Di Wu *School of Medicine, Nantong University, Nantong, 226001, People's Republic of China.
Jiachen Tan *School of Medicine, Nantong University, Nantong, 226001, People's Republic of China.
Faheem Ahmed KhanResearch Center for Animal Husbandry, National Research and Innovation Agency, Jakarta Pusat, 10340, Indonesia.
Nuruliarizki Shinta PandupuspitasariAnimal Science Department, Faculty of Animal and Agricultural Sciences, Universitas Diponegoro, Semarang, 50275, Indonesia.
Chunjie HuangSchool of Medicine, Nantong University, Nantong, 226001, People's Republic of China.ORCID 0000-0002-7784-6325

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Traditional Chinese medicines (TCMs) have been employed as a potent therapeutic modality within Chinese cultural contexts to address a spectrum of diseases. MicroRNAs (miRNAs) are endogenous, non-coding RNA (ncRNA) molecules that regulate genetic expression via post-transcriptional mechanisms. By modulating miRNA expression, TCMs have been proven to confer protective benefits, notably by facilitating apoptosis induction. Thus, exploring the molecular mechanisms implicating miRNAs within TCMs could offer potential avenues for developing novel strategies to mitigate various lethal illnesses. In this study, we aim to provide a concise overview delineating the contemporary understanding of the functions of TCMs in miRNA-mediated apoptosis across malignant and non-malignant pathologies, including cancer, neurological disorders, and cardiovascular diseases. This review will furnish valuable insights concerning the clinical utilization of TCMs in treatment and prevention across a spectrum of clinically relevant diseases and serve as a catalyst for the innovation of novel therapeutic agents to address these pathologies.

Indexed as

ApoptosisCardiovascular DiseasesDrugs, Chinese HerbalMedicine, Chinese TraditionalMicroRNAsNeoplasmsNervous System DiseasesAnimalsHumansSignal TransductionDrugs, Chinese HerbalMicroRNAsapoptosismalignant and non-malignant pathologiesmiRNAsmolecular basis of TCMs in diseasetraditional Chinese medicine

Identifiers

PMID40786249
PMCPMC12335846

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.