Evidence map›Paper›PMID 40786321›Full record

ArticleCureus2025

A Hematologic Twist: Zinc-Induced Copper Deficiency Mimicking Myelodysplastic Syndrome.

Mary Hinson Mims, Erin S Reid, Mary Grace Hash, Andreas Maddux

Abstract readCase Reports
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mary Hinson MimsInternal Medicine, Edward Via College of Osteopathic Medicine, Auburn, USA.
Erin S ReidInternal Medicine, Alabama College of Osteopathic Medicine, Dothan, USA.
Mary Grace HashInternal Medicine, Edward Via College of Osteopathic Medicine, Auburn, USA.
Andreas MadduxNephrology and Internal Medicine, University of Alabama at Birmingham (UAB) St. Vincent's East, Birmingham, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Zinc-induced copper deficiency is an underdiagnosed condition that can lead to systemic manifestations of hypocupremia, including anemia, neutropenia, ataxic myelopathy, spastic paresis, alopecia, and skin depigmentation. This case illustrates the harmful effects of zinc supplementation and zinc-containing denture adhesive in a 68-year-old man, ultimately leading to copper deficiency. It also underscores the importance of considering zinc toxicity in the differential diagnosis of patients presenting with unexplained cytopenias, bone marrow abnormalities, and related symptoms. Furthermore, this report highlights the need for clinicians to consider zinc toxicity-induced copper deficiency in the evaluation of unexplained pancytopenias, especially in the post-COVID era, where zinc supplementation has become increasingly prevalent.

Indexed as

denture adhesivesmyelodysplastic syndromessupplement risksunexplained anemiaunexplained neutropeniazinc excesszinc-induced hypocupremia

Identifiers

PMID40786321
PMCPMC12334246

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.