Evidence map›Paper›PMID 40787492›Full record

ArticleAnnals of medicine and surgery (2012)2025

METTL9 as a protein biomarker predicts the prognosis and immunotherapy response of skin-cutaneous melanoma.

Song Tang, Yiran Zhang, Simin Luo, Wendan Wang, Xunxin Wu, Xiaoxu Zhao, Yin Leng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of medicine and surgery (2012), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Song TangThe Second Department of General Surgery, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, China.ORCID https://orcid.org/0000-0001-5486-0979
Yiran ZhangDepartment of General Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, China.
Simin LuoBreast Tumor Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, P.R. China.
Wendan WangSchool of Computer Science, Beijing University of Posts and Telecommunications, Beijing, China.
Xunxin WuDepartment of Infectious Disease, The First Affiliated Hospital of Jinan University, Guangzhou, China.
Xiaoxu ZhaoDepartment of Infectious Disease, The First Affiliated Hospital of Jinan University, Guangzhou, China.
Yin LengThe Second Department of General Surgery, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The role of methyltransferase-like proteins (METTLs) in skin cutaneous melanoma (SKCM) remains unclear. This study investigates the expression of METTLs, particularly METTL9, in SKCM and its clinical significance. Through multiple database analyses and immunohistochemical experiments, we found that METTL9 is significantly upregulated in SKCM tissues, and its expression level is closely associated with tumor-node-metastasis stage, N stage, and ulceration status. Patients with high METTL9 expression have a poor prognosis and show a reduced response to immunotherapy. Furthermore, METTL9 is identified as an independent risk factor for poor prognosis in SKCM patients.

Indexed as

human methyltransferase-like proteinsMETTL9prognostic biomarkersskin cutaneous melanomatherapeutic targets

Identifiers

PMID40787492
PMCPMC12333701

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.