Chronic liver disease and radiation-induced second primary liver malignancy: a retrospective cohort based on SEER database 2010-2021.

Introduction: Cirrhotic patients are at a high risk of developing radiation-induced liver toxicities despite the modern safe radiation delivery techniques due to the low liver tolerance. Recent studies demonstrated a potential risk of second primary malignancies (SPMs) following radiotherapy (RT) with further investigations for strategies to decrease RT-induced SPMs. However, it is insufficiently addressed if developing liver SPMs is a serious adverse event following RT for cirrhotic patients. Thus, we aimed to quantitatively assess the risk of gastrointestinal (GI) and liver SPMs following RT in patients with liver fibrosis. Methods: The SEER*Stat beta software version 9.0.32 was used to obtain and analyze the data of patients with chronic liver disease diagnosed from 2010 to 2021. We sub-grouped patients according to the history of receiving RT for prior cancer treatment into two groups and excluded patients with unknown RT administration history. Results: We observed 215 cirrhotic patients developed GI SPMs (O/E = 2.76, Conclusion: Cirrhotic patients who received RT before had an increased risk for GI SPMs by three folds and a 12-fold increased risk for liver SPMs. However, who received no RT had an 8-fold increased risk for liver SPM. Thus, screening for HCC in cirrhotic patients exposed to RT is a must for early detection and better management outcome.