ArticleJournal of the American Chemical Society2025
Unusual O-H Activation-Initiated C-C Bond Cleavage Reaction by a Nonheme Fe Enzyme in Antifungal Nucleoside Biosynthesis.
Yanan Du, Julian Dong, Matthew M Draelos, Laura N Collazo-Perez, Sean H Majer, Amie K Boal, Kenichi Yokoyama
Abstract read
In one paragraphArticle in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
7 authors.
Yanan DuDepartment of Biochemistry, Duke University School of Medicine, Durham, North Carolina 27710, United States.ORCID 0000-0002-4438-139X Julian DongDepartment of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.
Matthew M DraelosDepartment of Chemistry, Duke University, Durham, North Carolina 27710, United States.
Laura N Collazo-PerezDepartment of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.
Sean H MajerDepartment of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.
Amie K BoalDepartment of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.ORCID 0000-0002-1234-8472 Kenichi YokoyamaDepartment of Biochemistry, Duke University School of Medicine, Durham, North Carolina 27710, United States.ORCID 0000-0001-5625-469X Funding
X-ray Scattering Technology CoreP30GM133893 · NIGMS · BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB · PI Sean McSweeney · 2019 to 2026
$38.6MMapping the Structural Basis for Mechanistic Diversity in Metalloenzyme SuperfamiliesR35GM119707 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI Amie K Boal · 2016 to 2026
$5.0MBiosynthesis of peptidyl nucleoside antifungal antibioticsR01GM115729 · NIGMS · DUKE UNIVERSITY · PI YOKOYAMA, KENICHI · 2015 to 2023
$3.1MNIGMS NIH HHS P30 GM133893NIGMS NIH HHS R01 GM115729NIGMS NIH HHS R35 GM119707
6 · The paper itselfAbstract
Fe(II)- and α-ketoglutarate (α-KG)-dependent enzymes catalyze diverse reactions, generally initiated by Fe
Indexed as
Antifungal AgentsNonheme Iron ProteinsNucleosidesCarbonAntifungal AgentsCarbonNonheme Iron ProteinsNucleosides
Identifiers
PMID40787846
PMCPMC12392984
What Socratic holds
Textmetadata
LicenceTDM
Read underepoch 390